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MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
ProteomicsLiquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation
Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they can cross the placenta and affect placental development remains u...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-01-21 | PXD059395 | Pride
Transporter Gestation exposure Transplacental transportation Lcms 
TranscriptomicsComparative transcriptional profiling provides insights into the evolution and development of the zygomorphic flower of Vicia sativa (Papilionoideae)
Background: Vicia sativa (the common vetch) possesses a predominant zygomorphic flower and belongs to the subfamily Papilionoideae, which is related to Arabidopsis thaliana in the eurosid II clade of the core eudicots. Each vetch flower consists of 21 concentrically arranged organs: the outermost fi...
ORGANISM(S): Vicia sativa 
2013-03-26 | E-GEOD-35437 | biostudies-arrayexpress
TranscriptomicsBCOR-regulated genes in human oculo-facio-cardio-dental syndrome
Oculo-facio-cardio-dental syndrome (OFCD) is a rare genetic disorder characterized by teeth with extremely long roots (radiculomegaly), and craniofacial, eye and cardiac abnormalities. The mutation of the transcriptional co-repressor BCOR has been identified as being responsible for oculo-facio-card...
ORGANISM(S): Homo sapiens 
2009-07-23 | E-GEOD-15214 | biostudies-arrayexpress
ProteomicsMass spectrometry based detergent-insoluble proteins of human cell lysates
The PXD project contains a project which aimed to identify protein evidences (missing proteins) from insoluble proteins from cell lysate by mass spectrometry. It involves the analysis of 3 human lung cell line and 3 liver cell lines,including the identification information and quantitative informa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079997 | MassIVE
ProteomicsComparison of LFQ and TMT-based quantitative proteomics towards toxicology research
Here, we aimed to compare two of the most commonly used global proteomics strategies, label-free quantification (LFQ) and tandem mass tag-based quantification (TMT) to identify the most suitable tool for toxicology research questions on the systemic level. Using a biological case study of HepG2 expo...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020248 | Pride
Toxicoproteomics Benzo[a]pyrene Tandem mass tag (tmt) Label free-quantification (lfq) Hepg2 
TranscriptomicsExpression data from early diphyodont morphogenesis in minature pig
The miniature pig is diphyodont, making it a valuable alternative model for understanding human tooth development and replacement. However, little is known about gene expression and function during swine odontogenesis. The goal of this study is to undertake the survey of differential gene expressio...
ORGANISM(S): Sus scrofa 
2014-12-23 | E-GEOD-53182 | biostudies-arrayexpress
ProteomicsDIA-based raw mass spectrometry proteomics data of oviduct in goat
DIA-based LC-MS/MS method was used to obtain follicular and luteal phase proteomics data from the oviducts of high- and low-fertility goats, and to mine the oviducts for biomarkers that regulate fertility in goats through bioinformatics analysis of differential proteins.
ORGANISM(S): Capra Hircus 
2022-11-13 | PXD038122 |
UnknownSingle-cell landscape of bronchoalveolar immune cells in patients with immune checkpoint inhibitor-related pneumonitis.
Not available
S-EPMC11455925 | biostudies-literature
MetabolomicsAdaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we ...

2022-04-22 | MTBLS4161 | MetaboLights
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