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ProteomicsA small-molecule inhibitor targeting AKR1C1 suppresses cell proliferation and metastasis in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by highly invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis and has gained attention as an anticancer dru...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031082 | Pride
Alantolactone  akr1c1  anticancer  target identification  non-small cell lung cancer 
ProteomicsURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. HEK293T cells were transfected with His-URI plasmid before anti-His immunoprecipitation and gel cutting. LC-MS/MS was performed to identify URI potential binding proteins.
URI keeps low levels of p53 in a TRIM28-MDM2 dependent manner, maintains SCD1 activity and accumulation of MUFAs, and subsequently promotes resistance to TKIs in cancer cell. URI-p53-SCD1 axis mediates resistance of TKIs and may explain why p53-wild type HCC still showed intrinsic resistance to TKIs...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD045407 | Pride
Uri 
ProteomicsProteomic Analysis of Human Nucleus Pulposus in Young and Elderly Individuals Using TMT Quantification
This project investigates the differential proteomic profiles of human nucleus pulposus samples from young and elderly individuals. Using Tandem Mass Tag (TMT) quantification, we aim to identify and compare protein expression differences between the two groups. The research explores the biological i...
ORGANISM(S): Homo Sapiens 
2025-06-23 | PXD065307 |
ProteomicsExploring the interaction proteins of Sub1 in aging cardiomyocytes by protein MS
After transferring the Sub1 Flag plasmid into HL-1 cells, the cells were treated with bleomycin for 24 hours, followed by immunoprecipitation using Flag magnetic beads and protein mass spectrometry.
ORGANISM(S): Mus Musculus 
2026-06-24 | PXD080102 |
ProteomicsMass spectrometric profiling of intermolecular disulfide bonds between ROMO1 and its targets
Mass spectrometric profiling of intermolecular disulfide bonds between ROMO1 and its targets
ORGANISM(S): Homo Sapiens 
2024-06-11 | PXD053027 |
ProteomicsAnalyze the post-translation modification of UVRAG
To explore the role of post-translational modification on UVRAG, we used tandem mass spectrometry (MS/MS) to analyze the UVRAG from cells.
ORGANISM(S): Homo Sapiens 
2022-06-14 | PXD034521 |
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