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ProteomicsThe autophagic protein FYCO1 controls TRAIL receptor induced apoptosis and is inactivated by caspase 8
Apoptosis and autophagy are programs of controlled cellular suicide or survival, closely interconnected at multiple levels to ensure balanced answers to stress signals, and often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end–directed transport of aut...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033760 | Pride
Apoptosis  autophagy  inflammation  death receptors  endosome maturation  lysosomal degradation  caspase 8  fyco1  ccz1 
ProteomicsTwo-Step Co-Immunoprecipitation (TIP) Enables an Efficient and Highly Selective Isolation of Native Protein-Complexes
Co-immunoprecipitation (co-IP) is the most frequently used technique for the isolation of protein-protein (PPI) or protein-nucleic acid interactions (PNI) under native expression conditions. A major disadvantage of co-IP is the abundance of non-specific binders that can impede downstream application...
ORGANISM(S): Homo sapiens (Human) 
2018-01-11 | PXD006700 | Pride
Immunoprecipitation Bridging Co-immunoprecipitation Monoclonal Nfkb Co-ip Btip Chip Primary cells Antibody Tip Polyclonal Ikk Chromatin Cd95 
ProteomicsLongitudinal Proteomic Fingerprinting in CSF of Nusinersen-Treated Patients with 5q-Associated Spinal Muscular Atrophy
Abstract Introduction: 5q-associated spinal muscular atrophy (SMA) is a motor neuron disease causing progressive alpha motor neuron degeneration, muscle atrophy, and weakness. Intrathecal therapy with the antisense oligonucleotide Nusinersen modifies the disease course. However, biomarkers for under...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054900 | Pride
Cerebrospinal fluid Tmt Nusinersen Spinal muscle atrophy Sma Csf 
ProteomicsFunctional marker in glioblastoma
To identify receptors and pathways active in glioblastoma (GBM) stem like cells (GSCs), we generated and screened thousands of monoclonal antibodies (mAbs) for preferential binding to primary cultures enriched in GSCs. This led to the identification of the integrin alpha 7 (ITGA7) as a major laminin...
ORGANISM(S): Homo sapiens (Human) 
2018-01-10 | PXD006069 | Pride
Glioblastoma  cancer stem cells  integrin alpha 7  glioma cell invasion  stem cell marker  high throughput antibody screening 
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