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TranscriptomicsNSD1 Mutations Generate a Genome-Wide DNA Methylation Signature
Sotos syndrome (SS) represents an important human model system for the study of epigenetic regulation; it is an overgrowth/intellectual disability syndrome caused by mutations in a histone methyltransferase, NSD1. As layered epigenetic modifications are often interdependent, we propose that pathogen...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-74432 | biostudies-arrayexpress
GenomicsChIP-Seq of ORC2 bound to third instar salivary gland DNA in WT and mutant Drosophila, analyzed by Illumina sequencing
We analyzed ORC2 ChIP-Seq from hand dissected salivary glands of wandering third instar larvae from OrR or SuUR Drosophila. Goals were to ascertain the difference in binding profile between salivary glands expressing and not expressing the Supressor of UnderReplication protein. One replicate is incl...
ORGANISM(S): Drosophila melanogaster 
2011-10-18 | E-GEOD-31899 | biostudies-arrayexpress
UnknownNSD1 mutations generate a genome-wide DNA methylation signature.
Not available
S-EPMC4703864 | biostudies-literature
UnknownAntagonistic effect of helpers on breeding male and female survival in a cooperatively breeding bird.
Not available
S-EPMC4557059 | biostudies-literature
ProteomicsIdentification of SEC61B as a novel regulator of calcium flux and platelet hyperactivity in diabetes mellitus
Platelet hyperactivity contributes to increased cardiovascular thrombosis in diabetes. Intracellular and released proteins control platelet activity however there are limited proteomic studies of the diabetic platelet. We isolated platelets from 34 patients without, and 42 patients with type 2 diabe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-19 | PXD049321 | Pride
Sec61b Calcium Er stress Diabetes Translocon Platelet 
UnknownAnti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.
Not available
S-EPMC10948883 | biostudies-literature
TranscriptomicsDNaseI/Array GM06990
The goal of this study was to map DNaseI sensitivity and DNaseI hypersensitive sites over the ENCODE regions in human lymphoblastoid cells (GM06990, Coriell). DNA fragments released from DNaseI cut sites in nuclear chromatin were collected and hybridized to the Nimblegen ENCODE array. DNaseI-fragme...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4334 | biostudies-arrayexpress
ProteomicsEffect of FAK K454R mutation or knockout on composition of extracellular matrix and associated membrane proteins in 3D culture of ID8 mouse ovarian surface epithelial cells
ID8 mouse ovarian surface epithelial cells with or without K454R mutant and knockout of FAK were cultured as spheroid cultures. The cells were hypotonically lysed and washed out, and the insoluble material was analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2019-08-30 | PXD013062 | Pride
Fak Id8 Epithelial Mouse 3d culture Ovarian 
UnknownDetection of engineered T cells in FFPE tissue by multiplex in situ hybridization and immunohistochemistry.
Not available
S-EPMC7979489 | biostudies-literature
UnknownAssaying the regulatory potential of mammalian conserved non-coding sequences in human cells.
Not available
S-EPMC2646272 | biostudies-literature
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