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TranscriptomicsTime course analysis of human colorectal cancer liver metastasis models under Sacituzumab Govitecan (SG) treatment or untargeted control
Human colorectal cancer organoids were injected intrasplenically to form liver metastasis in mice were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38 (ADC). Tumors were harvested at different time points: 0 h, 6 h, 24 h, 48 h,...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16849 | biostudies-arrayexpress
TranscriptomicsTime course analysis of human colorectal cancer organoid treatment with Sacituzumab Govitecan (SG) or untargeted control IgG1-SN-38
Human colorectal cancer organoids were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38. Samples were harvested at different time points under treatment {0h, 3h, 6h, 9h, 12h} as well as after drug washout at 12 h on the following...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16843 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing from human salivary glands from Sjogren's disease patients recruited in the TRACTISS randomized clinical trial
Sjogren's disease patients received Rituximab (anti-CD20 depleting monoclonal antibody) or placebo treatment. This study aims to identify the transcriptomic features of salivary gland biopsies, the target tissue of the autoimmune response in Sjögren’s disease. It examines transcriptomic changes in s...
ORGANISM(S): Homo sapiens 
2025-06-30 | E-MTAB-15225 | biostudies-arrayexpress
TranscriptomicsiCLIP-seq identifies direct binding of PETISCO complex to replication-dependent histone mRNAs in Caenorhabditis elegans embryos
This study uses individual-nucleotide resolution UV crosslinking and immunoprecipitation (iCLIP) to map the direct RNA-binding sites of the PETISCO complex in Caenorhabditis elegans embryos. When bound to TOST-1, PETISCO stabilizes replication-dependent histone mRNAs during oogenesis to ensure adequ...
ORGANISM(S): Caenorhabditis elegans 
2025-11-11 | E-MTAB-15713 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of murine thymic type 1 dendritic cells from competitive bone marrow chimeras containing both claudin-1–deficient and claudin-1–sufficient cells
The goal of the experiment is to determine the impact of Claudin 1 deficiency on the gene expression of thymic type 1 dendritic cells.
ORGANISM(S): Mus musculus 
2025-08-08 | E-MTAB-15468 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of mouse sympathetic ganglia cells under control, cold-exposure, and microbiota-depletion conditions
We performed scRNA-seq analysis on sympathetic ganglia, including the superior cervical ganglion (SCG), stellate ganglion (SG), and coeliac–superior mesenteric ganglion (CG-SMG). Comparative analysis of the transcriptomic profiling revealed molecularly distinct cell subtypes. We then performed scRNA...
ORGANISM(S): Mus musculus 
2025-11-23 | E-MTAB-15945 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced DNA methylation changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 M-BM-5M, 0.4 M-BM-5M and 2 M-BM-5M for 1, 2 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44173 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HEK293T control and ZAP-L or ZAP-S isoform knockout cells mock infected or infected with wild type HIV-1 or CpG-recoded HIV-1
The zinc finger antiviral protein (ZAP, also known as PARP13 or ZC3HAV1) is an antiviral factor that restricts the replication of a wide range of RNA and DNA viruses. It exerts its antiviral function primarily by binding specific sequences known as ZAP response elements (ZREs) within single-stranded...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15061 | biostudies-arrayexpress
TranscriptomicsRNA-seg of CD8+ T cells from colorectal cancer tumor tissues in wildtype and Lypd6−/− mice
RNA-sequencing analyses were performed in CD8+ T cells sorted from MC38 tumors of WT and Lypd6b−/− mice， To investigate the effects of Lypd6b gene knockout on CD8+ T cells in the colon cancer tumor microenvironment. Abstract Lypd6b is a newly discovered molecule associated with neuromodulation. Howe...
ORGANISM(S): Mus musculus 
2025-12-11 | E-MTAB-16060 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling of human embryonic stem cells carrying different levels of mtDNA heteroplasmy cultured in mTeSR Plus and E8 media.
Mitochondrial DNA mutations in components of the electron transport chain disrupt mitochondrial activity and can alter how cells take up and utilize nutrients. To investigate how mtND6 (Complex I) mutations reshape the transcriptional profile of human pluripotent stem cells, we performed bulk RNA se...
ORGANISM(S): Homo sapiens 
2026-06-06 | E-MTAB-17070 | biostudies-arrayexpress
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