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ProteomicsProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions.
Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is demonstrably enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. In U2OS cells expressing PAK4-B...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024464 | Pride
Lzts2 Pak4 Cdc42 Bioid Epithelial cells Protein kinase Cell junctions 
ProteomicsGreatwall kinase regulates SAC by controlling phosphorylation and activity of MPS1
The Greatwall/Mastl kinase is an essential gene, which regulates the phosphatase activity that counteracts the phosphorylation of Cdk1 substrates. Although Mastl-/- MEFs can enter mitosis, they are unable to complete mitosis due to chromosome segregation defects. Here, we show that Mastl is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004882 | Pride
Greatwall kinase/mastl/cyclin-dependent kinase/knockout mice/cdk1/mps1/sac 
ProteomicsPhosphoproteomics reveals network rewiring to a pro-adhesion state in Annexin-1-deficient mammary epithelial cells
Background Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulations of ANXA1 functions have been associated with tumorigenesis and metastasis events in several cancers. Though ANXA1 levels correlate wit...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-13 | PXD007051 | Pride
Breast cancer Proteomics Annexin-1 Adhesion Phosphoproteomics Network analysis Mammary epithelial cells 
ProteomicsA multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis
Targeted proteomic mass spectrometry is emerging as a salient clinical diagnostic tool to track protein biomarkers. Yet, its strong analytical properties have not been exploited in the diagnosis and typing of flavivirus. Here, we report the development of a highly sensitive and specific single-shot ...
ORGANISM(S): Flavivirus 
2019-03-25 | PXD006922 | Pride
Flavivirus. Targeted proteomics Dengue 
ProteomicsStructural determinants of heparinâ??transforming growth factor-β1 interactions and their effects on signalling
Transforming growth factor-Ã?1 (TGF-Ã?1, Uniprot: P01137) is a heparin-binding protein that has been implicated in a number of physiological processes, including the initiation of chondrogenesis by human mesenchymal stem cells (hMSCs). Here, we identify the molecular features in the protein and in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079921 | MassIVE
OtherFunctional Mapping of the Zebrafish Early Embryo Proteome and Transcriptome
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00444 PASS00444]]. Replicate: 2, experiment: G_120105_01_zebrafish_band3, file: folder summary. Published as part of J Proteome Res. 2014 Sep 17 . From the Abstract: {{i}} Zebrafish is a popular system for studying vertebrate developmen...
ORGANISM(S): Fish_e 
GPM32310004416 | GPMDB
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