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MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
UnknownLL-37 Inhibits TMPRSS2-Mediated S2' Site Cleavage and SARS-CoV-2 Infection but Not Omicron Variants.
Not available
S-EPMC12686126 | biostudies-literature
UnknownStrategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer.
Not available
S-EPMC4919707 | biostudies-literature
UnknownAdapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.
Not available
S-EPMC5522311 | biostudies-literature
ProteomicsProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its vital importance in the biogenesis of glycosylphosphatidylinositol-anchored proteins
The SEL1L-HRD1 protein complex of endoplasmic reticulum (ER)-associated degradation (ERAD) plays indispensable roles for many physiological processes in a substrate-specific manner; however, the nature of endogenous substrates remains largely elusive. Here we have developed a unique proteomics strat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-12-17 | PXD041803 | Pride
Endogenous substrates Pigk Disease mutants   Sel1l-hrd1 erad Proteomic screens Gpi-anchored proteins 
ProteomicsProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its vital importance in the biogenesis of glycosylphosphatidylinositol-anchored proteins
The SEL1L-HRD1 protein complex of endoplasmic reticulum (ER)-associated degradation (ERAD) plays indispensable roles for many physiological processes in a substrate-specific manner; however, the nature of endogenous substrates remains largely elusive. Here we have developed a unique proteomics strat...
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD041882 | Pride
Disease mutants Endogenous substrates Pigk Sel1l-hrd1 erad Proteomic screens Gpi-anchored proteins 
UnknownNon-contrast MR imaging of blood-brain barrier permeability to water.
Not available
S-EPMC6097906 | biostudies-literature
UnknownTranscriptomic analysis of adaptive mechanisms in response to sudden salinity drop in the mud crab, Scylla paramamosain.
Not available
S-EPMC5984308 | biostudies-literature
ProteomicsThe mechanism to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes
Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms in the ER; however, the crosstalk between these two pathways and its physiological significance remain unexplored. Here we report that SEL1L-HRD1 ERAD limits autophagy and that, when ERAD i...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD040899 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
ProteomicsCoalescence of endoplasmic reticulum fragments form a new quality-control compartment in adipocytes
Using a combination of state-of-the-art (ultra-) imaging, biochemical and biophysical techniques, this study not only uncover a new cellular quality-control compartment, but demonstrate a profound cellular adaptation capability and plasticity in dealing with misfolded proteins or protein aggregates ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD038310 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
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