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MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
ProteomicsSpatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization
To interrogate how ASZ1 regulates pachytene piRNA biogenesis, we performed ASZ1 immunoprecipitation and mass spectrometry (IP-MS) in adult WT testes to identify ASZ1-interacting proteins.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD069037 | Pride
ProteomicsCoalescence of endoplasmic reticulum fragments form a new quality-control compartment in adipocytes
Using a combination of state-of-the-art (ultra-) imaging, biochemical and biophysical techniques, this study not only uncover a new cellular quality-control compartment, but demonstrate a profound cellular adaptation capability and plasticity in dealing with misfolded proteins or protein aggregates ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD038310 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
ProteomicsThe mechanism to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes
Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms in the ER; however, the crosstalk between these two pathways and its physiological significance remain unexplored. Here we report that SEL1L-HRD1 ERAD limits autophagy and that, when ERAD i...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD040899 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
ProteomicsProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its vital importance in the biogenesis of glycosylphosphatidylinositol-anchored proteins
The SEL1L-HRD1 protein complex of endoplasmic reticulum (ER)-associated degradation (ERAD) plays indispensable roles for many physiological processes in a substrate-specific manner; however, the nature of endogenous substrates remains largely elusive. Here we have developed a unique proteomics strat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-12-17 | PXD041803 | Pride
Endogenous substrates Pigk Disease mutants   Sel1l-hrd1 erad Proteomic screens Gpi-anchored proteins 
ProteomicsProteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its vital importance in the biogenesis of glycosylphosphatidylinositol-anchored proteins
The SEL1L-HRD1 protein complex of endoplasmic reticulum (ER)-associated degradation (ERAD) plays indispensable roles for many physiological processes in a substrate-specific manner; however, the nature of endogenous substrates remains largely elusive. Here we have developed a unique proteomics strat...
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD041882 | Pride
Disease mutants Endogenous substrates Pigk Sel1l-hrd1 erad Proteomic screens Gpi-anchored proteins 
MetabolomicsThe gut microbiota-butyrate axis restores cardiomyocyte autophagy to alleviate Doxorubicin-induced cardiotoxicity

Abstract

Background Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is widely used for treating various malignancies. However, its clinical application is limited by dose-dependent cardiotoxicity (DOX-induced cardiotoxicity, DIC). Recent studies have shown that the gut microbiot...

2025-09-16 | MTBLS12997 | MetaboLights
MetabolomicsMetabolic Profiling of Escherichia coli-Based Cell-Free Expression Systems for Process Optimization
Biotechnology has transformed the production of various chemicals and pharmaceuticals due to its efficient and selective processes, but it is inherently limited by its use of live cells as 'biocatalysts.' Cell-free expression (CFE) systems, which use a protein lysate isolated from whole cells, have ...
2020-06-02 | MTBLS1079 | MetaboLights
ProteomicsMolecular Landscape of Atherosclerotic Plaque Progression: Insights from Proteomics
This dataset comprises proteomic profiles of 87 human carotid atherosclerotic plaques from patients undergoing carotid endarterectomy (CEA). The study employed an integrated approach using Data Independent Acquisition (DIA) proteomics. A total of 87 human carotid plaques were analyzed to identify an...
ORGANISM(S): Homo Sapiens 
2025-03-26 | PXD062283 |
UnknownComparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry.
Not available
S-EPMC9054878 | biostudies-literature
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