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TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
UnknownA mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
Not available
S-EPMC5789928 | biostudies-literature
ProteomicsHbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
In mammals, chromosome-wide regulatory mechanisms ensure a balance of X-linked gene dosage between males (XY) and females (XX). In female cells, expression of genes from one of the two X-chromosomes is curtailed, with selective accumulation of Xist-RNA, Xist-associated proteins, specific histone mod...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD054014 | Pride
Proteomics Mitotic Mouse Chromosomes 
UnknownA high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.
Not available
S-EPMC5167172 | biostudies-literature
UnknownHbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis.
Not available
S-EPMC12431858 | biostudies-literature
ProteomicsEffects of arbuscular mycorrhizal fungi on Pteris cretica L var. nervosa fronds antimony enrichment, morphology and proteome changes during antimony phytoremediation
Pteris cretica L var. nervosa is one of the dominent fern species at antimony mining area where arbuscular mycorrhizal fungi can be found as a symbiosis. The effect of AMF on fern exposed to long-term excessive Sb was pooly understood. The project applied this fern co-cultivting with or withour AMF ...
ORGANISM(S): Pteris cretica var. nervosa 
2024-01-19 | PXD012678 | Pride
Arbuscular mycorrhizal fungi Antimony phytoremediation Pteris cretica l var. nervosa Long-term exposure Fronds proteomic identification 
UnknownProtocol for using GRPath to identify putative gene regulation paths in complex human diseases.
Not available
S-EPMC9664398 | biostudies-literature
TranscriptomicsmicroRNA expression data from AG 1522 human fibroblasts post X-ray radiation
Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. We focused on microRNA microarray studies, and aimed to characte...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-59862 | biostudies-arrayexpress
TranscriptomicsmRNA Expression data from AG 1522 human fibroblasts post X-ray radiation
Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. We focused on mRNA microarray studies, and aimed to characterize...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-59861 | biostudies-arrayexpress
UnknownChromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation.
Not available
S-EPMC4845908 | biostudies-literature
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