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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsMoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae
A convergent screening strategy was employed to systematically identify mitophagy regulators within the IMM. The quantitative proteomic comparison between the WT and ΔMoatg1 mutant under nutrient-replete (CM) and nitrogen-starvation (CM-N) conditions was conducted using TMT-labeled quantitative prot...
ORGANISM(S): Pyricularia oryzae 70-15 
2026-09-14 | PXD075441 | Pride
Mitophagy Succinylation Cox6 Fungicide Magnaporthe oryzae 
ProteomicsElectroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
Electroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
ORGANISM(S): Rattus Norvegicus 
2022-11-29 | PXD038461 |
ProteomicsCharacterization of proteome variation during modern maize breeding
we used mass spectrometto perform an integrated analysis of proteome e in an association panel consisting of 98 maize inbred lines.
ORGANISM(S): Zea Mays 
2019-01-17 | PXD042776 |
UnknownShort-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial.
Not available
S-EPMC9478880 | biostudies-literature
UnknownClopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.
Not available
S-EPMC10928538 | biostudies-literature
ProteomicsThe pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Proteome analysis of Biotin- PLANE pull-down assays
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022747 |
UnknownToripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.
Not available
S-EPMC12371549 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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