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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
ProteomicsProteome profiling of N2a pretreated with ALDH2
Aldehyde dehydrogenase 2 family member (ALDH2) is a key mitochondrial dehydrogenase that functions in the detoxification of acetaldehyde, and endogenous 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde generated by polyunsaturated fatty acid peroxidation. In this study, we found that altered ALDH2 en...
ORGANISM(S): Mus Musculus 
2023-11-24 | PXD047209 |
ProteomicsProteome profiling of BV2 cells with altered ALDH2 enzyme activity
Aldehyde dehydrogenase 2 family member (ALDH2) is a key mitochondrial dehydrogenase that functions in the detoxification of acetaldehyde, and endogenous 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde generated by polyunsaturated fatty acid peroxidation. Whether ALDH2 activity altered microglia cell...
ORGANISM(S): Mus Musculus 
2023-11-24 | PXD047210 |
ProteomicsNovel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification
Immune-mediated necrotizing myopathy (IMNM) is a severe autoimmune myopathy with high clinical heterogeneity. Current classification relies on myositis-specific antibodies (MSA: anti-HMGCR, anti-SRP) but fails to explain differences in manifestations, interstitial lung disease (ILD) incidence, and s...
ORGANISM(S): Homo Sapiens 
PXD078154 |
ProteomicsProteomic study of Toxoplasma gondii infection in cibeaver
Proteomics in South China Agricultural University essentially refers to the study of protein characteristics at a large-scale level, including protein expression level, post-translational modification, protein-protein interaction and so on, so as to obtain an overall and comprehensive understanding ...
ORGANISM(S): Paguma Larvata 
2022-11-09 | PXD038083 |
ProteomicsProteomic profiling and tumor microenvironment characterization reveal molecular and immunological hallmarks of left-sided and right-sided colon cancer tumorigenesis
The protein landscapes of LSCC and RSCC were constructed, and the hallmarks of tumorigenesis and characteristics of TME for LSCC and RSCC were identified. These findings improved our understanding of LSCC and RSCC and may facilitate the development of diagnostic or therapeutic targets for LSCC and R...
ORGANISM(S): Homo Sapiens 
PXD042962 |
ProteomicsArrestin engagement of the metabotropic glutamate receptor mGlu5
Phosphorylation sites identified at the C-terminus of mGlu5 by mass spectrometry analysis
ORGANISM(S): Homo Sapiens 
PXD076479 |
ProteomicsSerum proteomics of individuals with MASLD under resistance starch intervention
Searching for baseline proteins that contribute to the individual response to RS intervention
ORGANISM(S): Homo Sapiens 
PXD068798 |
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