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ProteomicsThe catalytic activity of the kinase Zap-70 mediates basal signaling and negative feedback of the T cell receptor pathway
T cell activation must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells, while avoiding autoimmunity. Our knowledge of the mechanisms controlling the fine-tuning of T cell receptor (TCR) signaling and T cell activation is sti...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002023 | Pride
T cell Phosphoproteomics Lc-ms/ms 
ProteomicsLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell antigen receptor (TCR) signaling depends upon the kinases Lck and Zap70. Lck phosphorylates the TCR, facilitating Zap70 recruitment to the stimulated TCR. Lck also phosphorylates Zap70, relieving its auto-inhibition and activating its catalytic domain. Zap70 then phosphorylates the critical a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008258 | Pride
Jurkat t cell line Lat Tcr signaling Mice Lck Zap70 
UnknownPediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.
Not available
S-EPMC4538327 | biostudies-literature
UnknownModeling Human Cancer-induced Cachexia.
Not available
S-EPMC6733019 | biostudies-literature
UnknownBCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis.
Not available
S-EPMC10030045 | biostudies-literature
TranscriptomicsCalcium and Magnesium responses in Brassica rapa
A mapping population of Brassica rapa (BraIRRI, IMB211xR500) was grown under four external calcium and magnesium concentrations in controlled conditions. RNA was extracted and hybridised to the Affymetrix Brassica Exon 1.0 ST array. The aim of the experiment was to identify cis- and trans- expressio...
ORGANISM(S): Brassica rapa 
2014-05-21 | E-GEOD-44185 | biostudies-arrayexpress
UnknownAberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Not available
S-EPMC3580007 | biostudies-literature
UnknownLive-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion.
Not available
S-EPMC6231945 | biostudies-literature
UnknownSpinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
Not available
S-EPMC4537825 | biostudies-literature
UnknownA Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.
Not available
S-EPMC6346737 | biostudies-literature
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