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ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 normal pull down 4h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2017-06-02 | PXD005389 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 normal pull down 2h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005377 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 normal pull down 19h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005387 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 competitive pull down 2h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005378 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 competitive pull down 19h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005388 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, plestatins-3 competitive pull down 4h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005386 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, Ru-OH-2 normal pull down 4h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010318 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsTargeting the Scaffold Protein Plectin by an Organometallic as a Strategy to Inhibit Tumour Invasiveness- whole cell lysate of HCT 116 epithelial cells, Ru-OH-2 competitive pull down 4h
The inability of determining direct molecular targets of metal-based therapeutic agents beyond the platinum class is one of the major bottlenecks in their development. Here, we employ an integrated chemical proteomics and response profiling approach to identify and validate plestatins, based on an o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010319 | Pride
Ruthenium Response profiling Organometallics Target identification Metallodrugs Chemical proteomics Mechanism of action Plectin 
ProteomicsSchwann cell plasticity regulates neuroblastic tumor cell differentiation - phosphoproteomics
The remarkable plasticity of Schwann cells (SCs) is essential for nerve regeneration but also contributes to neuropathies and cancer progression. It has not yet been investigated whether the adaptive potential of SCs is manifested in stromal, tumor associated SCs characteristically found within a be...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022217 | Pride
Neuroblastoma Plasticity Ganglioneuroma Schwann cell Egfl8 Phosphoproteomics Stroma 
ProteomicsSchwann cell plasticity regulates neuroblastic tumor cell differentiation
The remarkable plasticity of Schwann cells (SCs) is essential for nerve regeneration but also contributes to neuropathies and cancer progression. It has not yet been investigated whether the adaptive potential of SCs is manifested in stromal, tumor associated SCs characteristically found within a be...
ORGANISM(S): Homo sapiens (Human) 
2021-01-13 | PXD018267 | Pride
Neuroblastoma Plasticity Ganglioneuroma Schwann cell Egfl8 Stroma 
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