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ProteomicsSelective Arylation of Selenocysteine of Thioredoxin Reductase 1 by an Organogold Compound: Expanding the Tool-Box of Metal-Templated Reactions in Cancer Cells - profiling
Cyclometalated gold(III) complexes have been reported to template C-S cross-coupling reactions in a biological environment and acting as modifies of cysteine residues. To broaden the scope of organogold complexes for covalent protein post-translational modification in cancer cells, an oxime-containi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD044966 | Pride
Arylation ∙ cancer ∙ chemoproteomics ∙ gold ∙ metals in medicine ∙ selenoprotein ∙ thioredoxin reductase 1 
ProteomicsA Gold-PROTAC degrades the oncogenic tyrosine kinase MERKT: Insights into the degradome from a steady-state system
Targeted protein degradation is a valuable strategy to eliminate disease-relevant proteins. Among other classes, proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce the proximity of a recruiter E3 ligase and the target protein of interest for ubiquitination and subsequent...
ORGANISM(S): Homo sapiens (Human) 
2026-07-27 | PXD067054 | Pride
Cancer  degradome  metallo-protac  protac  protein half-life  targeted protein degradation 
TranscriptomicsNanostring Profiling of the GBM Xenoline JX14 grown in monoculture in PDX or PSX media, or in triculture in triculture with macrophages and astrocytes in PSX
Nanostring microarray of the GBM Xenoline JX14P at 3 separate passages grown in PDX media (monoculture), PSX media (monoculture), or PSX media (indirect triculture).
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14811 | biostudies-arrayexpress
ProteomicsMultilevel Omics-Readouts of Perturbation Studies in vitro are Determined by Memory Effects from Subculture
Mass spectrometry-based omics technologies are of increasing relevance for drug discovery. In order to map drug treatments to biological pathways for mode of action (MoA) deconvolution, they rely on the determination of multiple testing corrected significant molecular events. The main contributors t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD039768 | Pride
Phosphoproteomics Reproducibility Multi-level omics Subculture Arsenic trioxide Mode of action deconvolution Proteomics Perturbation network Eicosadomics 
ProteomicsMultilevel Omics-Readouts of Perturbation Studies in vitro are Determined by Memory Effects from Subculture
Mass spectrometry-based omics technologies are of increasing relevance for drug discovery. In order to map drug treatments to biological pathways for mode of action (MoA) deconvolution, they rely on the determination of multiple testing corrected significant molecular events. The main contributors t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD051069 | Pride
Phosphoproteomics Reproducibility Multi-level omics Subculture Arsenic trioxide Mode of action deconvolution Proteomics Perturbation network Eicosadomics 
ProteomicsHigh-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficult to identify in current clinical practice. As a result, biology driven risk stratification and therapy assignment for medulloblastoma constitutes a major challenge...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD051319 | Pride
Medulloblastoma Dia Proteomics Myc Immunohistochemistry 
ProteomicsHigh-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficult to identify in current clinical practice. As a result, biology driven risk stratification and therapy assignment for medulloblastoma constitutes a major challenge...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD051235 | Pride
Proteomics Medulloblastoma Myc Immunohistochemistry 
ProteomicsPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis – subcellular in vitro profiling
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plec...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD060086 | Pride
Hepatocellular carcinoma  plectin  plecstatin-1 Target Metastasis 
UnknownNational Survey of United Kingdom Paediatric Allergy Services.
Not available
S-EPMC9804618 | biostudies-literature
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
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