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ProteomicsA viral ADP-ribosyltransferase attaches RNA chains to host proteins
The mechanisms by which viruses hijack their host’s genetic machinery are of current interest. When bacteriophage T4 infects Escherichia coli, three different ARTs (ADP-ribosyltransferases) reprogram the host’s transcriptional and translational apparatus 1,2 through ADP-ribosylation using nicotinami...
ORGANISM(S): Escherichia coli 
2023-06-01 | PXD038910 | Pride
Escherichia coli Rnaylation T4 phage Lc-ms/ms 
ProteomicsMammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment
Fully-grown oocytes are transcriptionally silent and must stably maintain mRNAs needed for oocyte meiotic maturation and early embryonic development. However, where and how mammalian oocytes store maternal mRNAs is unclear. Here, we report that mammalian oocytes accumulate mRNAs in a mitochon...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-25 | PXD036974 | Pride
Mouse Oocytes Lc-esi-ms/ms Dda Mrna storage 
ProteomicsAnalysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry
Protein–DNA interactions are key to the functionality and stability of the genome. Identification and mapping of protein–DNA interaction interfaces and sites is crucial for understanding DNA-dependent processes. Here, we present a workflow that allows mass spectrometric (MS) identification of protei...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2020-10-20 | PXD020290 | Pride
Mass spectrometry Protein-dna interactions Uv-cross-linking 
ProteomicsMolecular insights into THUMPD2-mediated m2G methylation of the U6 snRNA
MMARY THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053619 | Pride
Methylation Snrna Crosslinking mass spectrometry Methyltransferase 
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