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MetabolomicsThe HuMet Repository: Watching human metabolism at work
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights
MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
ProteomicsNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic def...
ORGANISM(S): Caenorhabditis elegans 
2020-01-13 | PXD015644 | Pride
Mitophagy Wrn Nad+ Nmnat1 Aging 
MetabolomicsPhysiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes
Human metabolism is highly variable. At one end of the spectrum, defects of enzymes, transporters, and metabolic regulation result in metabolic diseases such as diabetes mellitus or inborn errors of metabolism. At the other end of the spectrum, favorable genetics and years of training combine to res...
2022-02-07 | MTBLS2104 | MetaboLights
UnknownWerner syndrome in a Lebanese family.
Not available
S-EPMC8995352 | biostudies-literature
UnknownWerner syndrome presenting as early-onset diabetes: A case report.
Not available
S-EPMC8902380 | biostudies-literature
TranscriptomicsComparative expression analysis between CRP (TTHA1437) deletion mutant and wild-type of T. thermophilus HB8
We observed the expression profile of the total mRNA of crp (TTHA1437) deletion mutant of Thermus thermophilus HB8 strain grown in a rich (TT) medium at 70oC compared with that of wild type. Keywords: cell type comparison Three wild-type and mutant T. thermophilus HB8 strains were each pre-cultured ...
ORGANISM(S): Thermus thermophilus HB8 
2010-05-27 | E-GEOD-7166 | biostudies-arrayexpress
UnknownWerner syndrome gene variants in human sarcomas.
Not available
S-EPMC2813347 | biostudies-literature
ProteomicsCrosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.
To evaluate the downstream effects of anti-Ly6a crosslinking, we examined the effect of anti-Ly6a antibodies on CD8+ T cell activity in the presence and absence of target tumor cells by high-resolution mass spectrometry proteomic analyses. Spleen cells were isolated from gp10025–33 TCR transgenic mi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-04 | PXD050734 | Pride
Uvb Cd8 t cells Cancer immunotherapy T cells metabolism 
UnknownThe spectrum of WRN mutations in Werner syndrome patients.
Not available
S-EPMC1868417 | biostudies-literature
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