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ProteomicsQuantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry
Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC are tissue-resident cells with lung-specific properties compared to bone marrow-derived MSC. Assessing relevant molec...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD006419 | Pride
Human 
ProteomicsProteomic characterization of mesenchymal lung cells
Mesenchymal cells in human lung are heterogneous and can display a large variation in both functional properties and spatial localization. However it remain unclear to witch extent these observed cell population represent different cell types or just different cellular states. Furthermore, the lack ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-11 | PXD029028 | Pride
Human Lung Mesenchymal cell 
ProteomicsQuantifying extracellular matrix turnover in human lung scaffold cultures
Tissue engeneering using biological scaffolds are a promising technique for solving the shortage of donor organs for patients suffering of end stage organ faliure. We introduced stable isotope labeling with amino acids in a tissue culture setting, which enabeled us to distinguish between the biologi...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007995 | Pride
Human Ecm Lung Silac 
ProteomicsHuman plasma proteome changes during inhaled allergen challenge
Inhaled allergen challenge of subjects with allergic asthma allows the study of mechanisms involved in allergen-induced airway inflammation. The objective of this study was to identify changes in the plasma proteome associated with a late phase response (LPR) causing airway obstruction occurring 4-8...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD027091 | Pride
Human Late phase response Allergy Asthma Plasma 
ProteomicsAlveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
The structure of alveoli is critical for proper lung function, the extracellular matrix (ECM) that forms these delicate structures need to be maintained throughout life, when this fails, patients suffer from conditions such as emphysema or lung fibrosis. The alveolar walls are lined by alveolar epit...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD034531 | Pride
Human Ecm Ipf Copd Lung Remodeling Alveolar epithelium 
TranscriptomicsFunctional tissue specific MSC in lung-transplanted patients with and without bronchiolitis obliterans syndrome (BOS) - a potential source for cell-therapy?
Background: Mesenchymal stromal cells (MSC) have been proposed as a future cell based therapy for lung diseases like bronchiolitis obliterans syndrome (BOS). Theoretically, it might be beneficial to use lung resident MSC already adapted to the pulmonary environment. We therefore aimed to compare lun...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-74163 | biostudies-arrayexpress
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