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TranscriptomicsTranscription profiling of nude mice tumor biopsies generated by the injection of mesenchymal stem cells (MSC)
Transformed MSC were injected subcutaneously into the flank of athymic CD1 nude mice (C/River). Biopsies of 1.5 cm spindle cell tumours were taken.
ORGANISM(S): Homo sapiens 
2006-12-26 | E-MEXP-562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells transformed with lentiviral vectors of TERT, E6, SV40 and RAS
Mesenchymal Stem Cells are transformed by step-wise stable transfection with lentiviral vectors of TERT, E6, E7, SV40, and Ras.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-MEXP-563 | biostudies-arrayexpress
TranscriptomicsLoss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [NSC34]
Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neu...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-56503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human mesenchymal stem cells after induction of differentiation
Human mesenchymal stem cells were induced to differentiate into adipocytes using a specific induction cocktail. Transcriptional profiles were obtained at the specified timepoints after induction of differentiation.
ORGANISM(S): Homo sapiens 
2008-09-08 | E-MEXP-858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Kaposi sarcoma, normal skin and primary cells
Identification of the relationships of Kaposi sarcoma (KS), normal skin to various cell cultures. The effects of KS herpes virus, the infectious cause of KS, on infected endothelial cells are also investigated.
ORGANISM(S): Homo sapiens 
2004-08-01 | E-MEXP-66 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of Medulloblastoma
An observational experiment to RNA-seq profile 331 primary tumours from patients diagnosed with Medulloblastoma.
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-10767 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of primary tumours derived from patients with medulloblastoma
An observational experiment to methylation profile 161 primary tumours from patients diagnosed with Medulloblastoma.
ORGANISM(S): Homo sapiens 
2022-11-01 | E-MTAB-10754 | biostudies-arrayexpress
TranscriptomicsExpression data from MSC-treated monocytes
Chronic inflammation leading to pro-inflammatory macrophage infiltration contributes to the pathogenesis of type 2 diabetes and subsequently the development of diabetic nephropathy. Mesenchymal stem cells (MSCs) possess unique immunomodulatory and cytoprotective properties making them an ideal candi...
ORGANISM(S): Homo sapiens 
2015-11-10 | E-GEOD-65561 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of resistant and vulnerable motor neuron subtypes in amyotrophic lateral sclerosis
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements. Pathological studies have confirmed that there is relative sparing of the cranial motor nuclei of the oculomotor, trochlear and abducens nerves, although pathological changes resembling those seen i...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-40438 | biostudies-arrayexpress
TranscriptomicsChildren's Oncology Group Study 9906 for High-Risk Pediatric ALL
PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profile...
ORGANISM(S): Homo sapiens 
2009-06-25 | E-GEOD-11877 | biostudies-arrayexpress
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