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ProteomicsMelanoma NRAS - Cooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock
In the present work we propose a new therapy for NRAS mutant melanoma. Simultaneous inhibition of MEK and ROCK caused induction of BimEL , PARP, and Puma, and hence apoptosis. In vivo, MEK and ROCK inhibition suppressed growth of established tumors. Our findings warrant clinical investigation of the...
ORGANISM(S): Homo sapiens (Human) 
2015-03-11 | PXD000528 | Pride
Phosphoproteome Melanoma Wholeproteome Nras 
ProteomicsTargeting Menin in T-Lineage Acute Lymphoblastic Leukemia
The efficacy of menin inhibition was evaluated in 14 primary T-ALL samples with diverse genetic backgrounds using ziftomenib. Sensitivity was not correlated with HOXA expression or KMT2A rearrangements, and in vivo treatment significantly reduced tumor burden in xenograft models without notable toxi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-05 | PXD065179 | Pride
Acute leukemia Menin inhibiton T-all 
ProteomicsTargeting Menin in T-Lineage Acute Lymphoblastic Leukemia
The efficacy of menin inhibition was evaluated in 14 primary T-ALL samples with diverse genetic backgrounds using ziftomenib. Sensitivity was not correlated with HOXA expression or KMT2A rearrangements, and in vivo treatment significantly reduced tumor burden in xenograft models without notable toxi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-05 | PXD065185 | Pride
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