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ProteomicsThe exon junction complex component CASC3 is a major effector of nonsense-mediated mRNA decay in human cells
In metazoans, the exon junction complex (EJC) is a central component of spliced messenger ribonucleoprotein particles (mRNPs). CASC3 has been reported to be a core component of the EJC and to be crucial for assembly, the splicing regulating function of the EJC and nonsense-mediated mRNA decay (NMD)....
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD015754 | Pride
Exon junction complex Splicing Nonsense-mediated mrna decay 
ProteomicsAuto-phosphorylation at serine 166 regulates RIP kinase 1 mediated cell death and inflammation
Receptor interacting kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induces cell death by activating apoptosis and necroptosis, howe...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-23 | PXD014097 | Pride
Inflammation Cell death Phosphorylation 
ProteomicsSkeletal muscle-specific methyltransferase METTL21C trimethylates p97 and regulates autophagy-associated protein breakdown
Protein aggregates and cytoplasmic vacuolization are major hallmarks of multisystem proteinopathies (MSP) that lead to muscle weakness. Here, we identify METTL21C as a novel skeletal muscle-specific lysine methyltransferase. Insertion of a -galactosidase cassette into the Mettl21c mouse locus reveal...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-05-04 | PXD008145 | Pride
Proteomics Methylation Proteostasis 
ProteomicsmTORC1 regulates GRASP55-dependent unconventional secretion in response to stress
In cells, several cargoes are delivered to the cell surface or the extracellular space via unconventional secretion routes. GRASP55 is a Golgi protein that regulates unconventional secretion of distinct proteins and controls the assembly and membrane stacking of Golgi cisternae. Recent work suggeste...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020331 | Pride
Grasp55 Golgi Cellular stress response Mtorc1 Tsc2 Unconventional secretion Rapamycin 
ProteomicsSingle cell RNA-seq analysis links respiratory dysfunction to an extracellular matrix-specific damage response
Energy metabolism and extracellular matrix function are closely connected to orchestrate and maintain tissue organization, but the crosstalk is poorly understood. Here, we used scRNA-seq analysis to uncover the importance of respiration for extracellular matrix homeostasis in mature cartilage. Genet...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027109 | Pride
Cartilage Respiration Ecm 
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