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TranscriptomicsIdentification of sigB inhibitors in L. monocytogenes
The extensively studied intracellular pathogen, L. monocytogenes, is an ideal model for identifying small-molecule agents for treating bacterial infections. By selecting specific biological targets in L. monocytogenes, which are common to Gram-positive pathogens, we could extrapolate drug discovery ...
ORGANISM(S): Listeria monocytogenes 10403S 
2011-12-06 | E-GEOD-16887 | biostudies-arrayexpress
Transcriptomicsregulation of Listeria monocytogenes internalin-like genes by Ï?B and PrfA as revealed by subgenomic microarray analyses
The Listeria monocytogenes genome contains more than 20 genes that encode cell surface-associated proteins termed internalins, which are characterized by the presence of multiple leucine-rich repeats. Subsets of internalin genes have been reported previously as transcriptionally regulated by the st...
ORGANISM(S): Listeria monocytogenes 
2010-06-11 | E-GEOD-6421 | biostudies-arrayexpress
TranscriptomicsSigma B in Listeria monocytogenes strains from different lineages
Listeria monocytogenes strains classify into at least three distinct phylogenetic lineages. Correlations exist between lineage classification and source of bacterial isolation, e.g., human clinical and food isolates usually classify into either lineage I or II, however, human clinical isolates are ...
ORGANISM(S): Listeria monocytogenes 
2010-06-01 | E-GEOD-21427 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes Transcriptome with RNA-Seq
The stationary phase stress response transcriptome of the human bacterial pathogen Listeria monocytogenes was defined using RNA sequencing (RNA-Seq) with the Illumina Genome Analyzer. Specifically, bacterial transcriptomes were compared between stationary phase cells of L. monocytogenes 10403S and ...
ORGANISM(S): Listeria monocytogenes 
2010-01-05 | E-GEOD-15651 | biostudies-arrayexpress
TranscriptomicsCharacterization of the SigB-PrfA regulatory network in Listeria monocytogenes
Listeria monocytogenes SigB and PrfA are pleiotropic regulators of stress response and virulence gene expression, which have been shown to co-regulate genes in L. monocytogenes. We performed whole genome transcriptional profiling in the presence of PrfA* and active SigB, to identify the overlaps be...
ORGANISM(S): Listeria monocytogenes 
2010-05-19 | E-GEOD-11347 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes Sigma B, but not PrfA, shows strain specific contributions to growth under salt stress, and prolongated lag phase of a sigB null mutant across strains
Listeria monocytogenes is well known to have the ability to survive and grow under a variety of stress conditions. The ability to survive and grow under osmotic stress conditions in particular appears to be important for both growth in certain foods and food associated environments as well as for ho...
ORGANISM(S): Listeria monocytogenes 
2013-07-20 | E-GEOD-49056 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes Grown at Refrigeration Temperature Shows Reduced Acid Survival and an Altered Transcriptional Response to Acid Shock
Survival of the foodborne pathogen Listeria monocytogenes in acidic environments (e.g., stomach and low pH foods) is vital to its transmission. L. monocytogenes grows at temperatures as low as 2M-BM-0C, and refrigerated, ready-to-eat foods have been sources of L. monocytogenes outbreaks. The purpose...
ORGANISM(S): Listeria monocytogenes 
2011-06-30 | E-GEOD-22672 | biostudies-arrayexpress
UnknownSelect Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epithelial cells.
Not available
S-EPMC1317312 | biostudies-literature
TranscriptomicsTranscriptional response of Listeria monocytogenes h7858 and f6854 to lactate and acetate
The organic acids lactate and diacetate are commonly used in combination in ready-to-eat foods because they show synergistic, i.e. greater than additive, ability to inhibit the growth of Listeria monocytogenes. Full genome microarrays were used to investigate the synergistic transcriptomic response...
ORGANISM(S): Listeria monocytogenes 
2011-11-03 | E-GEOD-25195 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing based analysis of Listeria monocytogenes 10403S::ΔBCHL Prha-sigH and ΔBCHL Prha
In this study, RNA-seq was used to compare the transcriptomes of Listeria monocytogenes 10403S::ΔBCHL Prha-sigH and ΔBCHL Prha. RNA-seq was performed on ΔBCHL Prha-sigH and ΔBCHL Prha RNA samples representing three independent biological replicates at log phase in Brain Heart Infusion (BHI) b...
ORGANISM(S): Listeria monocytogenes 10403S 
2016-02-11 | E-GEOD-73008 | biostudies-arrayexpress
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