Wild type versus reference pool. Reference pools from either the CuSO4 or BCS timecourse were compared with wildtype cells taken from mid-log cultures.
Saccharomyces cerevisiae cells were exposed to a copper chelator (100uM BCS) for 48 hours. Samples were compared to the zero hour timepoint at 0.5, 1, 2, 3, 4, 24 and 48 hours.
A gene expression study using microarray analysis was performed to elucidate the underlying mechanism leading to embryonic lethality in homozygous Commd1 null (Commd1-/-) mouse embryos. A gene expression profile of 9.5 dpc Commd1-/- embryos were generated and were compared to a gene expression profi...
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
High density SNP microarrays provide insight into the genomic events that occur in diseases like cancer by their capability to measure both LOH and genomic copy numbers. Where currently available methods are restricted to the use of fresh frozen tissue, we now describe the design and validation of c...
Recent studies in comparative genomics demonstrate that inter-species comparisons represent a powerful tool for revealing both conserved and specialized biological processes across large evolutionary distances. All cells need to adjust to environmental fluctuations in metal levels since both metal ...
BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.
RESULT: We systematically investigate circulating metabolites in a cohort of 5...
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 63 peripheral blood ...
