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ProteomicsSynaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD006326 | Pride
Mouse Neuron Gtp 
ProteomicsEndogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders
Disrupted in schizophrenia 1 (DISC1) has been implicated in contributing to a number of psychiatric diseases and neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed towards understanding the function...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD007103 | Pride
Disc1 Neural Neural progenitor 
ProteomicsDevelopmental profile of core postsynaptic density protein complexes integrates signaling components of brain disorders
The postsynaptic density (PSD) contains a collection of scaffold proteins used for the assembly of synaptic signaling complexes and disruption of this signaling machinery might be implicated in a variety of brain disorders. However, it is not known how the core-scaffold machinery associates this col...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-22 | PXD006277 | Pride
Neuron Synaptic Psd 
ProteomicsIntegrated Proteomic and Multi-Omic Characterizations of the Synapse Reveal RNA Processing Factors and Ubiquitin Ligases Associated with Neurodevelopmental Disorders
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry to characterize the synapse in multiple biological models including the fetal human br...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-03-09 | PXD020933 | Pride
Induced neurons Synaptic Fetal brain Psd 
UnknownIdentification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification.
Not available
S-EPMC7982854 | biostudies-literature
UnknownDetection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.
Not available
S-EPMC3805485 | biostudies-literature
TranscriptomicsGenome wide transcriptional profiling of HIV positive and negative children with active tuberculosis, latent TB infection and other diseases
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-39941 | biostudies-arrayexpress
UnknownDiagnosis of childhood tuberculosis and host RNA expression in Africa.
Not available
S-EPMC4069985 | biostudies-literature
UnknownHistone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.
Not available
S-EPMC5778085 | biostudies-literature
UnknownPrevalence and architecture of de novo mutations in developmental disorders.
Not available
S-EPMC6016744 | biostudies-literature
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