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ProteomicsTriple Null, a soybean bred to lack major seed allergen P34 and bioactive lectin and kunitz trypsin inhibitor
Seeds, including soybean (Glycine max), contain bioactive proteins with anti-nutritional and immunological properties that affect metabolism and assimilation of seed derived nutrients and as allergens that can induce escalating adverse immune responses. The presence of anti-nutritional proteins requ...
ORGANISM(S): Glycine max 
2022-02-23 | PXD000967 | Pride
Null Seed Soybean Allergen 
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownIn Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
Not available
S-EPMC6093436 | biostudies-literature
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse aorta and vSMCs response to dioxin
We compared the global gene expression profiles of C57BL/6 mice aortas with the profiles of cultured vascular smooth muscle cells (vSMC) from the same mice, and determined whether gene responses to dioxin exposure in the vSMCs would be predictive of responses in the aorta.
ORGANISM(S): Mus musculus 
2003-10-29 | E-MEXP-23 | biostudies-arrayexpress
UnknownPerformance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.
Not available
S-EPMC11565374 | biostudies-literature
TranscriptomicsTargeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome
Myelodysplastic Syndromes (MDS) result from expansion of defective hematopoietic stem/progenitor clones. There is an urgent need to develop targeted therapies capable of eliminating the defective MDS clones. We identified that IRAK1, an immune modulating kinase, is overexpressed and hyperactivated i...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-46346 | biostudies-arrayexpress
UnknownA functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
Not available
S-EPMC3867393 | biostudies-literature
UnknownInterleukin-6 signaling drives fibrosis in unresolved inflammation.
Not available
S-EPMC3919204 | biostudies-literature
UnknownComparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.
Not available
S-EPMC4469977 | biostudies-literature
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