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ProteomicsAnalysis of changes in protein expression in inferior colliculus
One of the most robust behavioural phenotypes in the Fmr1-/ymouse is an increased susceptibility to AGS, which models the sensory hypersensitivity and epileptiform activity seen in FX patients (Berry-Kravis, 2002; Musumeci et al., 1991; Yan et al., 2004; Yan et al., 2005). Multiple therapeutic strat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD036296 | Pride
Ags Inferior colliculus Proteasome Fragile x 
ProteomicsMYC sensitises cells to apoptosis by driving energetic demand
The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sens...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034517 | Pride
Nucleotide catabolism Pentose phosphate pathway Myc Energy Metabolic flux Nucleotide biosynthesis Apoptosis Glutamine Adenylate kinase 
ProteomicsA commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component
Condensin complexes compact and disentangle chromosomes in preparation for cell division. Commercially available antibodies raised against condensin subunits have been widely used to characterise their cellular interactome. Here we have assessed the specificity of a polyclonal antibody (Bethyl A302-...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-14 | PXD022664 | Pride
Swi/snf Condensin Antibody Ncaph2 Cross-react 
ProteomicsRegional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021270 | Pride
Maxquant Q exactive plus Immunoprecipitation On-beads digest 
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
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