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We report the application of paired-end RNA sequencing for high throughput profiling of the Xenopus transcriptome in 23 distinct developmental stages. In total, we obtained over 900 million reads and the deep coverage allowed us to examine the transcriptome in detail. First, we found that ~150 genes...
ORGANISM(S): Xenopus (Silurana) tropicalis 
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Mus musculus 
Proximity labelling using transient expression of the same exogenous BirA*-RAB18 construct in wild-type HeLa cells and in otherwise isogenic RAB3GAP1-, RAB3GAP2- and TRAPPC9-null HeLa cell lines.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD016336 | Pride
These data are from two wild-type HeLa clones (WT1, WT2) and two TBC1D20-null clones (5H2, 7H5), each analysed in triplicate.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD016233 | Pride
These data are from two wild-type RPE1 clones (WT11, WT20), a RAB18-null clone, a TBC1D20-null clone, a RAB3GAP1-null clone and a RAB3GAP2-null clone, each analysed in triplicate.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD016326 | Pride
Proximity labelling using transient expression of the same exogenous BioID2(Gly40Ser)-SEC22A construct in wild-type HeLa cells and in otherwise isogenic RAB3GAP1-, RAB3GAP2- and RAB18-null HeLa cell lines.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD016404 | Pride
The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability o...
ORGANISM(S): Homo sapiens 
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
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