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TranscriptomicsIdentification and function of non-coding small RNAs in Streptococcus pneumoniae
We report here an experimental search for small non-coding RNAs in a low GC, gram-positive, human pathogenic bacteria Streptococcus pneumoniae. Based on the bioinformatic analyses by Livny et al. (2006, Nucleic Acids Res. 34:3484-93), we tested 36 candidates by Northern analyses and confirmed the e...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-14 | E-GEOD-14688 | biostudies-arrayexpress
TranscriptomicsConditional Essentiality of vicK (walKSpn) Histidine Kinase for Anaerobic Growth of Streptococcus pneumoniae D39
The VicRK two-component system of S. pneumoniae (Pneumococcus) is a member of the essential WalRK (YycFG) family found in low G+C gram positive bacteria. Previously, we showed that phosphorylated VicR response regulator (RR) is essential, because of its strong positive regulation of the pcsB gene, w...
ORGANISM(S): Streptococcus pneumoniae 
2013-01-04 | E-GEOD-19752 | biostudies-arrayexpress
TranscriptomicsCis- and trans-Regulation of Pneumococcal spxB
Pyruvate oxidase encoded by spxB is a major virulence factor in the human respiratory pathogen Streptococcus pneumoniae. During aerobic growth, SpxB synthesizes large amounts of H2O2 and acetyl phosphate, which can serve as a phosphoryl group donor to response regulators and be converted to ATP. Spx...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-26 | E-GEOD-7109 | biostudies-arrayexpress
TranscriptomicsCapsule Mediates the Cell Shape of pcsB Mutants in Serotype 2 Streptococcus pneumoniae
PcsB is a protein of unknown function that plays a critical role in cell division in Streptococcus pneumoniae and other ovococcus species of Streptococcus. We constructed isogenic sets of mutants expressing different amounts of PcsB in laboratory strain R6 and virulent serotype 2 strain D39 to evalu...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-22 | E-GEOD-13107 | biostudies-arrayexpress
TranscriptomicsThe metalloregulatory site in Streptococcus pneumoniae AdcR, a zinc-activated MarR-family repressor
Streptococcus pneumoniae D39 AdcR (adhesion competence repressor) is the first metal-sensing member of the MarR (multiple antibiotic resistance repressor) family to be characterized. Expression profiling of a ∆adcR strain grown in liquid culture under microaerobic conditions revealed that transcr...
ORGANISM(S): Streptococcus pneumoniae 
2010-10-01 | E-GEOD-21506 | biostudies-arrayexpress
TranscriptomicsA new structural paradigm in copper resistance in a human pathogen
Copper is essential for both innate and adaptive immune function and copper resistance has emerged as an important determinant of virulence of microbial pathogens. In the human pathogen Streptococcus pneumoniae (Spn), cytoplasmic copper resistance is mediated by an operon encoding the copper-respons...
ORGANISM(S): Streptococcus pneumoniae 
2013-05-24 | E-GEOD-39176 | biostudies-arrayexpress
TranscriptomicsRoles of relSpn in Stringent Response, Global Regulation, and Virulence of Serotype 2 Streptococcus pneumoniae D39
Transcriptome analysis of D39 rel+Spn and delta-relSpn strains treated with mupirocin revealed relSpn-independent (translation stress), relSpn-dependent (stringent response), and delta-relSpn-dependent changes suggesting that relSpn and (p)ppGpp amount play wide-ranging homeostatic roles in pneumoco...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-15 | E-GEOD-14750 | biostudies-arrayexpress
UnknownThe power of genetic diversity in genome-wide association studies of lipids.
Not available
S-EPMC8730582 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
UnknownA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Not available
S-EPMC9388392 | biostudies-literature
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