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ProteomicsProteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies
Withaferin A (WA), a natural steroid lactone from the plant Withania Somnifera, has been used for many years in traditional Ayurveda medicine to treat inflammation-related conditions, such as ulcers and rheumatism. Today, WA is most often studied because of its antitumor properties. Although many in...
ORGANISM(S): Homo sapiens (Human) 
2018-02-23 | PXD006528 | Pride
Withaferin a Quantitative chemoproteomics Quantitative differential expression analysis Multiple myeloma 
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-GEOD-55728 | biostudies-arrayexpress
ProteomicsIdentification and Quantitative Analysis of Cellular Proteins Affected by Treatment with Withaferin A using a SILAC-based Proteomics Approach
Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as ‘‘Ashwagandha’’. A number of published reports suggest various uses for WA including its function as an anti-inflammatory and anti-angiogenic drug molecule. The effects of WA at ...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-10 | PXD003032 | Pride
Proteomics Mass spectrometry Silac Withaferin a 
ProteomicsWithaferin A inhibits LFA-1-stimulated ZAP70 activity and T-cell motility
a steroidal lactone withaferin A (WFA) can inhibit T-cell motility, which is crucial for adaptive immune responses as well as autoimmune reactions. Tandem mass spectrometry identified WFA-interactome in human T-cells that were stimulated to migrate via cross-linking of the lymphocyte function-associ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026508 | Pride
T-lymphocytes Inflammation Migration Withaferin a Kinome 
GenomicsGene expression changes in THP1 AML cells following Withaferin A exposure
Gene expression changes in THP1 AML cells following Withaferin A exposure
PRJNA741523 | ENA
GenomicsSmall RNA next generation sequencing of miRNAs in MCF7 cells derived mammosphere treated with withaferin A
Small RNA next generation sequencing of miRNAs in MCF7 cells derived mammosphere treated with withaferin A
PRJNA750717 | ENA
GenomicsNovel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells
Novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells
PRJNA663908 | ENA
GenomicsSmall RNA next genration sequencing of miRNAs in Withaferin A treated MDA-MB-231 cells.
Small RNA next genration sequencing of miRNAs in Withaferin A treated MDA-MB-231 cells.
PRJNA760502 | ENA
TranscriptomicsA natural plant derived compound, Withaferin A exploits the stress pathway to induce antitumor immunity
Analysis of the global effect of plant derived compound Withaferin A on gene expression in rat her-2/neu expressing murine cancer cells at an early time point of 6hrs post treatment. Pathway analyses were performed to determine which metabolic pathways were significantly affected by the Withaferin A...
ORGANISM(S): Mus musculus 
2014-12-31 | GSE43374 | GEO
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | GSE55728 | GEO
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