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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
UnknownAtypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.
Not available
S-EPMC7843956 | biostudies-literature
UnknownTixagevimab/cilgavimab or placebo for COVID-19 in ACTIV-2: Safety, pharmacokinetics and neutralizing and anti-drug antibodies.
Not available
S-EPMC11927737 | biostudies-literature
ProteomicsIdentification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1
Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we rep...
ORGANISM(S): Homo sapiens (Human) 
2019-07-19 | PXD011356 | Pride
Trf2 Shelterin Dj1 Pgk1 Telomere Stress 
UnknownComparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.
Not available
S-EPMC9349574 | biostudies-literature
UnknownACTIV-2: A Platform Trial for the Evaluation of Novel Therapeutics for the Treatment of Early COVID-19 in Outpatients.
Not available
S-EPMC10469341 | biostudies-literature
ProteomicsThe phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. One of the best studied proteins undergoing LLPS is Fused...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015834 | Pride
Fused in sarcoma Liquid-liquid phase separation Amyotrophic lateral sclerosis 
UnknownCharacterization of Treatment Resistance and Viral Kinetics in the Setting of Single-Active Versus Dual-Active Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2.
Not available
S-EPMC11326811 | biostudies-literature
UnknownSafety and Efficacy of Combined Tixagevimab and Cilgavimab Administered Intramuscularly or Intravenously in Nonhospitalized Patients With COVID-19: 2 Randomized Clinical Trials.
Not available
S-EPMC10134004 | biostudies-literature
UnknownEnsitrelvir for the Treatment of Nonhospitalized Adults with COVID-19: Results from the SCORPIO-HR, Phase 3, Randomized, Double-blind, Placebo-Controlled Trial.
Not available
S-EPMC12272848 | biostudies-literature
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