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ProteomicsMitoxantrone impacts on proteoform abundance in HR proficient and deficient ovarian cancer cells
Mitoxantrone (MX) is regularly used to treat several cancers, yet despite its long history in the clinic, recent studies continue to unveil novel protein targets that may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity. A better understanding of...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD069401 | Pride
Ovarian cancer Mitoxantrone 
ProteomicsSurveying the proteome-wide landscape of Mitoxantrone and examining drug-sensitivity in BRCA1-deficient ovarian cancer using quantitative proteomics
Mitoxantrone (MX) is regularly used to treat several cancers, yet despite its long history in the clinic, recent studies continue to unveil novel protein targets that may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity. A better understanding of...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD069034 | Pride
Human Mitoxantrone Ovarian cancer 
ProteomicsEndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010589 | Pride
Human Pancreas beta cell Glucose stimulation 
ProteomicsCTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD009541 | Pride
Brct dna damage lc-msms 
Proteomics293FT Cell Endogenous FANCA Protein-Protein Interactions
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a p...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010570 | Pride
Fanca Protein-protein interaction Fanconi anemia complementation group a 
ProteomicsProteomics of KRAS mutated and non-transformed pancreas cells treated with ethanol
The goal for this study was to determine the effects of ethanol on pancreas cells and examine how ethanol influences protein expression in non-transformed and mutant KRAS cells. We performed TMT-labeled proteomics of non-transformed (hTERT-HPNE E6/E7) and KRAS mutated (hTERT-HPNE E6/E7/K-RasG12D) hu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD030180 | Pride
Ethanol Tmt Pancreas Kras 
ProteomicsSART1 modulates Poly-(ADP-Ribose) accumulation and PARP1 chromatin localization
Protein modular domains mediate signal transduction events in all living cells and play a significant role in the cellular responses to the environment. The BRCT domain is a versatile protein modular domain that is a key integrator of signals in the DNA damage response. To identify components of the...
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD047970 | Pride
Sart1 Parp1 Brct domain Dna damage response 
TranscriptomicsmiRNA profiling of Melanoma Cell lines and Normal Melanocytes
To identify microRNAs potentially involved in melanomagenesis we compared microRNA transcription profiles between melanoma cell lines and cultured melanocytes. miRNA microarrays were manufactured by Agilent Technologies (Santa Clara, CA), and contain 20-40 features targeting each of 470 human miRNAs...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-25653 | biostudies-arrayexpress
UnknownMercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon.
Not available
S-EPMC6406457 | biostudies-literature
MetabolomicsDifferent carboxyl-rich alicyclic molecules proxy compounds select distinct bacterioplankton for oxidation of dissolved organic matter in the mesopelagic Sargasso Sea

Marine dissolved organic matter (DOM) varies in its recalcitrance to rapid microbial degradation. DOM of varying recalcitrance can be exported from the ocean surface to depth by subduction or convective mixing and oxidized over months to decades in deeper seawater. Carboxyl-rich alicyclic molecul...

2024-02-20 | MTBLS3512 | MetaboLights
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