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ProteomicsEndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010589 | Pride
Human Pancreas beta cell Glucose stimulation 
ProteomicsCTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD009541 | Pride
Brct dna damage lc-msms 
Proteomics293FT Cell Endogenous FANCA Protein-Protein Interactions
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a p...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD010570 | Pride
Fanca Protein-protein interaction Fanconi anemia complementation group a 
ProteomicsProteomics of KRAS mutated and non-transformed pancreas cells treated with ethanol
The goal for this study was to determine the effects of ethanol on pancreas cells and examine how ethanol influences protein expression in non-transformed and mutant KRAS cells. We performed TMT-labeled proteomics of non-transformed (hTERT-HPNE E6/E7) and KRAS mutated (hTERT-HPNE E6/E7/K-RasG12D) hu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD030180 | Pride
Ethanol Tmt Pancreas Kras 
UnknownHeterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis.
Not available
S-EPMC6688907 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownHigher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10156147 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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