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TranscriptomicsTranscription profiling of human monocytes reveals leukotriene D4 induces gene expression through cysteinyl leukotriene type I receptor.
Background: Cysteinyl leukotrienes (cysLTs) are important mediators of innate immune responsiveness and chronic inflammatory diseases. CysLTs acting through cysteinyl leukotriene receptors may influence the migration and activity of cells such as eosinophils, monocytes and dendritic cells. Objective...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7807 | biostudies-arrayexpress
UnknownLeukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.
Not available
S-EPMC5560436 | biostudies-literature
TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
UnknownCytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Not available
S-EPMC2519846 | biostudies-literature
TranscriptomicsCooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24869 | biostudies-arrayexpress
UnknownSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells.
Not available
S-EPMC4329332 | biostudies-literature
UnknownLeukotriene E4 is a full functional agonist for human cysteinyl leukotriene type 1 receptor-dependent gene expression.
Not available
S-EPMC4735867 | biostudies-literature
GenomicsCompararitve Triprimate Peripheral Blood DNA Methylome
DNA methylation is critical for development and is strongly associated with gene regulation. Variation in the DNA methylome between closely related species may reveal unique functional adaptation. We have implemented a novel inter-primate DNA methylation genome-wide analysis between human, chimpanze...
ORGANISM(S): Macaca mulatta 
2014-02-01 | E-GEOD-48942 | biostudies-arrayexpress
UnknownHuman-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases.
Not available
S-EPMC4062055 | biostudies-literature
UnknownIL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor.
Not available
S-EPMC11969324 | biostudies-literature
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