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ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-22 | PXD004020 | Pride
Mouse Glycoproteomics Sucrose fractionation Directed ms Skeletal muscle 
ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD002846 | Pride
Mouse Directed ms (dms) Skeletal muscle Membrane protein complexes 
ProteomicsDiscovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
Aberrant activation of androgen receptor (AR)-dependent transcriptional programs is a hallmark of human prostate cancers. At the molecular level, ligand-mediated AR activation is coordinated through spatial and temporal protein-protein interactions (PPIs) involving AR-interacting proteins, which we ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-20 | PXD002861 | Pride
Androgen Transcription Intracellular trafficking Prostate cancer Protein trafficking Mass spectrometry-based proteomics Androgen receptor Golgi membrane 
ProteomicsAndrogen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells
Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic re...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002913 | Pride
Androgen Human prostate cancer cells Lectin affinity purification 
ProteomicsAndrogen Receptor Activity is Regulated Through the Mobilization of Cell Surface Receptor Networks
The aberrant expression of androgen receptor (AR)-dependent transcriptional programs is a defining pathology of the development and progression of prostate cancers. Transcriptional cofactors that bind AR are critical determinants of prostate tumorigenesis. To gain a deeper understanding of the prote...
ORGANISM(S): Homo sapiens (Human) 
2015-09-03 | PXD002596 | Pride
Lncap Prostate cancer Androgen receptor 
UnknownDiscovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription.
Not available
S-EPMC5009256 | biostudies-literature
GenomicsEGAS00001000775-sc-2023-03-15T11:18:45Z - samples
Candidate diagnostic variants reported into DECIPHER by 4 April 2022, annotated with clinical and automated pathogenicity assertions (see DOI: 10.1056/NEJMoa2209046). Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland, Wright et al, NEJM 2023.
EGAD00001010137 | EGA
UnknownDiscovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases.
Not available
S-EPMC8592995 | biostudies-literature
UnknownCabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor-Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial.
Not available
S-EPMC5652872 | biostudies-literature
UnknownMolecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy.
Not available
S-EPMC5083101 | biostudies-literature
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