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TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
UnknownA person-centered analysis of ethnic-racial socialization patterns and their identity correlates in multiracial college students.
Not available
S-EPMC8298278 | biostudies-literature
ProteomicsProteomic signatures of the serological response to flu vaccination in a large human cohort study
This project investigates the serum proteomic signatures of the serological response to flu vaccination. We profiled the serum proteome of 160 flu vaccine recipients from a cohort study conducted in 2019-2020 season, with DIA-MS based proteomics. We compared the protein level between low and high re...
ORGANISM(S): Homo sapiens (Human) 
2022-11-17 | PXD036718 | Pride
Human cohort Serum proteomics Flu vaccination 
ProteomicsMechanism of protein abundance-independent 3′UTR-regulated JMJD3 activity in human cells
The 3′UTR in the KDM6B mRNA can control the cellular activity of the produced KDM6B/JMJD3 protein, but the mechanism is unclear. To examine whether 3′UTR-dependent JMJD3 protein complexes are responsible for the observed 3′UTR-dependent protein activity, KDM6B cDNA expression constructs with or with...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072448 | Pride
TranscriptomicsAn RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex
Purpose: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, myelinating oligodendrocytes, microglia, endothelial cells, and pericytes from mouse cerebral cortex. We g...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-52564 | biostudies-arrayexpress
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
ProteomicsSerum proteomics in a cohort of COVID patients and healthy controls
This project investigates the serum proteome patterms in recovered COVID patients compared to that in healthy controls. Specifically, serum saamples from 29 recovered patients and 29 age, sex, and race matched healthy controls were collected and subject to DIA-MS proteomics. A fraction of the serum ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD036597 | Pride
Dia-ms Serum proteomics Recovered covid patients Healthy controls 
TranscriptomicsSorted tumor RNA-seq of syngeneic murine mutant IDH1 ICC tumor model treated with IDH1 inhibitor against vehicle
IDH1 is the most commonly mutated metabolic gene across human cancers, with the highest mutational frequency observed in AML, glioma, chondrosarcoma, and intrahepatic cholangiocarcinoma. Mutations of the hot spot R132 codon alter the activity of the IDH1 enzyme, resulting in the NADPH-dependent conv...
ORGANISM(S): Mus musculus 
2021-11-23 | E-MTAB-11112 | biostudies-arrayexpress
TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that bi-allelic inactivation of Lkb1 and Pten in the mouse lung led to SCC that recapitulated the histology, gene expression and microenvironment found in human disease. Lkb1/Pten-null ...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54351 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 1] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune comp...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47672 | biostudies-arrayexpress
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