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TranscriptomicsICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer
Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeu...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-36924 | biostudies-arrayexpress
ProteomicstRNA modification profile of PA14 transposon insertion mutant library
Transfer RNA (tRNA) modifications have emerged as critical posttranscriptional regulators of gene expression that impact diverse biological and disease processes. While there is extensive knowledge about the enzymes installing the dozens of tRNA modifications – the tRNA epitranscriptome – very littl...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2025-08-04 | PXD053297 | Pride
Trna modification Ucbpp-pa14 Mrm Lcms 
TranscriptomicsStable Patterns of Gene Expression Regulating Carbohydrate Metabolism Determined by Geographic Ancestry
Individuals of African descent in the United States suffer disproportionately from diseases with a metabolic etiology (obesity, metabolic syndrome, and diabetes), and from the pathological consequences of these disorders (hypertension and cardiovascular disease). Using a combination of genetic/geno...
ORGANISM(S): Homo sapiens 
2009-10-30 | E-GEOD-12959 | biostudies-arrayexpress
TranscriptomicsTemporal transcriptomics suggest that twin-peaking genes reset the clock
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the true nature of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissect...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-72095 | biostudies-arrayexpress
UnknownRemoscope: a label-free imaging cytometer for malaria diagnostics.
Not available
S-EPMC11601755 | biostudies-literature
TranscriptomicsTumor-microenvironment interactions studied by zonal transcriptional profiling of squamous cell lung carcinoma
To better understand the interaction between tumor cells and their microenvironment with regard to mechanisms of invasion, total RNA was isolated from the inner-tumor, tumor invasion front, adjacent lung and distant normal lung tissue from 18 patients with squamous cell lung carcinoma using punch-ai...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31446 | biostudies-arrayexpress
UnknownPersonal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.
Not available
S-EPMC8273876 | biostudies-literature
TranscriptomicsElevated MAOA Expression Enhances Tumor Growth In-vivo and Alters Transcriptional Profiles
Subcutaneous xenografts were derived utilizing either PC3 cells engineered to stably overexpress MAOA or empty vector controls in mice receiving docetaxel treatment. Tumor gene expression was profiled using Agilent gene expression microarrays. Custom Agilent 44K whole human genome expression oligon...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-53944 | biostudies-arrayexpress
Genomicsena-DATASET-dkfz_b062-21-02-2018-14:40:33:479-591 - samples
This dataset contains whole exome sequencing data from 24 patients. The Agilent SureSelect Human All Exon 50-Mb target enrichment kit was used to capture all human exons for deep sequencing. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-...
EGAD00001003973 | EGA
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
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