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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
TranscriptomicsRNA-seq data in cardiac tissues from cardiomyocyte-specific Acsl4 knockout mice after transverse aortic constriction
In order to investigate the differentially expressed genes in Acsl4 knockout after TAC (Transverse aortic constriction) or sham surgery. The experiment was divided to four groups including sham-operated Acsl4 flox/flox mice (FS), sham-operated Acsl4 knockout mice (KS), TAC-operated Acsl4 flox/flox m...
ORGANISM(S): Mus musculus 
2024-08-26 | E-MTAB-14383 | biostudies-arrayexpress
ProteomicsProteome of extracellular vesicles derived from breast cancer cells
MDA-MB-231 cells were irradiated with 10 Gy X-rays and the medium was harvest for extracellular vesicles isolation 24 hours post-irradiation. Proteins carrying by EVs of irradiated and control cells were then analysed by LC-MS.
ORGANISM(S): Homo Sapiens 
2024-04-22 | PXD051650 |
ProteomicsHEK cells expressing miRFP680-P2A-GFP, emiRFP670-P2A-GFP, emiRFP703-P2A-GFP, miRFP713-P2A-GFP and miRFP720-P2A-GFP
HEK cells transiently transfected with pAAV-CAG-NIR-FPs-P2A-GFP plasmids were processed using Mini MS Sample Prep kit according to the manufacture protocol. Extracted peptides were analyzed using Orbitrap Fusion Lumos mass spectrometer (Thermo Fisher) in data-independent acquisition (DIA) mode. We ...
ORGANISM(S): Homo Sapiens 
2023-06-07 | PXD042781 |
ProteomicsSpatially Resolved Proteomics via Tissue Expansion
Spatially resolved proteomics is an emerging approach, however, it remains technically challenging due to the complexity of the tissue microsampling techniques and mass spectrometry analysis of nanoscale specimen volumes. Here, we describe an expansion proteomics method ProteomEx, a combination of t...
ORGANISM(S): Mus <genus> 
2022-11-04 | PXD037950 |
ProteomicsCo-IP and LC-MS/MS analysis for probing the binding partners of ITGBL1 in fibroblasts
Co-IP, LC-MS/MS and cluster analysis of the binding proteins for targeted ITGBL1 protein using the ITGBL1 antibody or control IgG in ITGBL1-overexpressing WI-38 cells.
ORGANISM(S): Homo Sapiens 
2020-01-19 | PXD017182 |
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