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ProteomicsTargeting upstream Hippo-pathway kinases releases the scaffolder WWC1 to promote synaptic plasticity and long-term memory in mice
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an important component of AMPAR hetero-protein complexes. However, genetic analysis sugges...
ORGANISM(S): Homo sapiens (Human) 
2024-05-03 | PXD050351 | Pride
Kibra Wwc1 Memory Kinobead Msti 
UnknownWWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT.
Not available
S-EPMC10394084 | biostudies-literature
UnknownHnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Not available
S-EPMC11081807 | biostudies-literature
UnknownLow expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome.
Not available
S-EPMC6609559 | biostudies-literature
UnknownWWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway.
Not available
S-EPMC11301351 | biostudies-literature
GenomicsHippo pathway component WWC1 is a key regulator of apoptosis and photosensitivity in lupus keratinocytes
Hippo pathway component WWC1 is a key regulator of apoptosis and photosensitivity in lupus keratinocytes
PRJNA817599 | ENA
UnknownWWC1 genotype modulates age-related decline in episodic memory function across the adult life span.
Not available
S-EPMC3989426 | biostudies-literature
UnknownWWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.
Not available
S-EPMC7264477 | biostudies-literature
UnknownLong non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p/WWC1 axis.
Not available
S-EPMC11896158 | biostudies-literature
Methylation profilingHippo pathway component WWC1 is a key regulator of apoptosis and photosensitivity in lupus keratinocytes
Skin inflammation and photosensitivity are common manifestations of cutaneous and systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Non-lesional SLE skin exhibits increased UVB-driven cell death that persists in culture, supporting a potential role for epigenet...
ORGANISM(S): Homo sapiens 
2023-07-06 | GSE198972 | GEO
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