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UnknownKinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks.
Not available
S-EPMC7537592 | biostudies-literature
UnknownKinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.
Not available
S-EPMC5663466 | biostudies-literature
ProteomicsTargeting upstream Hippo-pathway kinases releases the scaffolder WWC1 to promote synaptic plasticity and long-term memory in mice
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an important component of AMPAR hetero-protein complexes. However, genetic analysis sugges...
ORGANISM(S): Homo sapiens (Human) 
2024-05-03 | PXD050351 | Pride
Kibra Wwc1 Memory Kinobead Msti 
UnknownKinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells.
Not available
S-EPMC9662893 | biostudies-literature
ProteomicsCompetitive kinobead profiling of RAF inhibitors
Kinase enrichment was performed using kinobeads followed by LC–MS/MS to profile target engagement/competition by RAF inhibitors. HEK293T lysates overexpressing 185 protein kinases were prepared in modified RIPA buffer, pre-incubated with DMSO or inhibitor, then incubated with kinobeads to enrich kin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD075247 | Pride
Human Lc-ms Kinase 
ProteomicsPhosphoproteomic profiling of kinobead-enriched fractions from LF-268-treated HCT-116 cells via SILAC-based quantification
SILAC-based phosphoproteomic profiling of kinase-enriched fractions from HCT-116 cells treated with the DFG-out pan-RAF inhibitor LF-268 to characterize kinase signaling responses. Cells were metabolically labeled and treated with 1 µM LF-268 or DMSO for 1 hour, followed by serial kinobead enrichmen...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD075307 | Pride
Lc-msms Phosphoproteomics Human Kinase Dda 
ProteomicsKinobead profiling of PITCOINs1-3
Phosphatidylinositol 3-kinase type 2a (PI3KC2a) and related class II PI 3-kinase isoforms are of rising biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signalling, angiogenesis, and platelet morphology and function. Herein we report the developmen...
ORGANISM(S): Homo sapiens (Human) 
2022-08-24 | PXD032284 | Pride
Pulldowns Pi3kc2a Kinobeads 
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo sapiens (Human) 
2017-12-01 | PXD005336 | Pride
Target Mass spectrometry Chemical proteomics Kinase inhibitors Clinical kinase inhibitors Selectivity Lc-ms/ms 
ProteomicsAdaptive resistance to Afatinib in non-small cell lung cancer cells in attenuated by Ca2+ depletion
Targeted therapies against oncogenic receptor tyrosine kinases are showing promising results in the clinic. However, despite the initial response, most patients become resistant. The majority of research regarding resistance has been focused on acquired resistance occurring after an extensive time o...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008454 | Pride
Egfr  adaptive resistance  non-small lung cancer  tyrosine kinase inhibitors  calcium signaling 
ProteomicsProfiling of kinase-dependent signaling networks by kinobead/LC-MS analyses of phosphorylation and protein complexes
Kinase-catalyzed protein phosphorylation is fundamental to eukaryotic signal transduction, regulating most cellular processes. Kinases are also frequently dysregulated in cancer, inflammatory diseases and degenerative disorders, and because they can be inhibited with ATP-competitive molecules they n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-10-24 | MSV000084499 | MassIVE
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