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ProteomicsCross-linking MS supporting: Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome
The nucleocapsid N is one of four structural proteins of the coronaviruses. Its essential role in genome encapsidation makes it a critical therapeutic target for COVID-19 and related diseases. However, the inherent disorder of full-length N has hampered its structural analysis. Here, we describe a s...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2025-07-21 | PXD052584 | Pride
Cross-linking Xl-ms Sars-cov-2 n 
ProteomicsNative mass spectrometry of an allosteric heterodimer of SARS-CoV-2
The capability of native MS to probe protein-protein and protein-ligand interactions was exemplified with the allosteric heterodimer from SARS-CoV-2 consisting of the nonstructural proteins (nsp) nsp10 and nsp16. Complex dynamics, allostery, and ligand binding were shown. A metadata Excel file, 'nsp...
ORGANISM(S): Escherichia Coli Bl21(de3) (ncbitaxon:469008) 
2023-08-28 | MSV000092776 | MassIVE
ProteomicsCytoplasmic capping enzyme interactome
Formaldehyde crosslinking and Proximity-dependent biotinylation methods were applied to study the cytoplasmic capping enzyme interactome via 1D-LC-MS/MS. The raw data were searched against Uniprot human database modified to contain our designed protein sequences using the Thermo Proteome Discoverer ...
ORGANISM(S): Homo Sapiens (human) 
2018-08-30 | PXD010368 | JPOST Repository
ProteomicsStructure elucidation for tunable hetero-assembly of a plant PDX1.2/PDX1.3 pseudoenzyme-enzyme pair
Mass spectrometry raw data including peptide mapping, and top down liquid chromatography mass spectrometry for Arabidopsis PDX1.2/PDX1.3 homo- and hetero-complexes produced using cell-free expression. Purified proteins from cell-free expression were digested using trifluoroethanol protocol for pepti...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2020-04-06 | MSV000085233 | MassIVE
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