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TranscriptomicsPancreatic islet expression profiling in diabetes prone C57BLKS/J mice vs C57BL6/J mice.
C57BLKS/J mice are susceptible to diabetes, because of islet dysfunction, whereas C57BL6/J mice are not. Differences in gene expression between the two strains may account for this sensitivity. Furthermore these differences may only be evident in the hyperstimulated (diabetic or hyperglycemic) state...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-11257 | biostudies-arrayexpress
TranscriptomicsBase J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination
Base J and H3.V promote RNA Polymerase (RNAP) II termination within polycistronic gene clusters in the kinetoplastid species Trypanosoma brucei. Although base J has been shown to promote RNAP II termination in the related kinetoplastid species Leishmania major and Leishmania tarentolae, the role of ...
ORGANISM(S): Leishmania major 
2016-07-20 | E-GEOD-77632 | biostudies-arrayexpress
TranscriptomicsIdentification of candidate susceptibility and resistance genes of mice infected with Streptococcus suis type 2
There were four groups:control A/J mice;control B6 mice;SS2-infected A/J mice;SS2-infected B6 mice.The RNA samples of four groups were sent to Biostar Genechip Inc. (Shanghai, China) for microarray hybridization. The pooled RNA sample from each group was hybridized to one Illumina mouse Genome Beadc...
ORGANISM(S): Mus Musculus 
2012-02-09 | E-MTAB-745 | biostudies-arrayexpress
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
TranscriptomicsGenome-wide microRNA expression induced by TNF
We sequenced microRNAs from bone marrow derived macrophages derived from the control (WT) and RBP-J conditional knockout mice (RBP-J KO; Rbpjf/f; LysM Cre). Examination of differential microRNA expression levels induced by TNF as well as regulated by RBP-J in bone marrow derived macrophages.
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-72966 | biostudies-arrayexpress
TranscriptomicsExpression data comparing human DKK1 and control vector transfected murine osteochondrosarcoma cells (MOS-J)
Canonical Wnt signaling controls proliferation and differentiation of osteogenic progenitor cells, and tumor-derived secretion of the Wnt antagonist Dickkopf-1 (Dkk1) is correlated with osteolyses and metastasis in many bone malignancies. However, the role of Dkk1 in the oncogenesis of primary osteo...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-43112 | biostudies-arrayexpress
TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
TranscriptomicsOrientation-specific RAG activity in chromosomal loop domain contribute to Tcrd V(D)J recombination during T cell development
T cell antigen receptor δ (Tcrd) variable region exons are assembled by RAG-initiated V(D)J recombination. Here, we employ a high throughput method to map hundreds of thousands of RAG-initiated Tcrd D segment (Trdd1 and Trdd2) rearrangements in developing thymocytes. We find that Trdd2 joins direct...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-79892 | biostudies-arrayexpress
UnknownUtilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability.
Not available
S-EPMC6906732 | biostudies-literature
TranscriptomicsComparison of the gene expression profiles between iPS-OSH, iPS-J, ESC and MEF.
iPS-OSH was the novel iPS cells generated from our lab, the microarray analysis was used for determining the gene expression profiles of iPS-OSH. iPS-J was provided from Dr. Yamanaka (Riken, APS0001). Microarray analysis was used to compare the difference of gene expression profiles in iPS-OSH, iPS-...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-31822 | biostudies-arrayexpress
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