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TranscriptomicsSpatial organisation of the X inactivation center
We report the application of Chromosome Conformation Capture Carbon-copy (5C) to a 4.5 Mb stretch of the mouse X chromosome encompassing the X inactivation center locus. We uncover a series of discrete 200kb-1Mb topologically associating domains (TADs). These align with several domain-wide epigenomi...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-35721 | biostudies-arrayexpress
TranscriptomicsX chromosome dosage compensation via enhanced transcriptional elongation in Drosophila males (Untreated)
MSL (Male-specific lethal) complex increases transcription on the single X chromosome of Drosophila males in order to equalize expression of X-linked genes between males (XY) and females (XX). The increase in transcript levels correlates with MSL- dependent acetylation of histone H4 at K16 within th...
ORGANISM(S): Drosophila melanogaster 
2010-12-22 | E-GEOD-25321 | biostudies-arrayexpress
TranscriptomicsX chromosome dosage compensation via enhanced transcriptional elongation in Drosophila males (Control & MSL2 RNAi)
MSL (Male-specific lethal) complex increases transcription on the single X chromosome of Drosophila males in order to equalize expression of X-linked genes between males (XY) and females (XX). The increase in transcript levels correlates with MSL- dependent acetylation of histone H4 at K16 within th...
ORGANISM(S): Drosophila melanogaster 
2011-03-03 | E-GEOD-25887 | biostudies-arrayexpress
TranscriptomicsX-chromosome inactivation in monkey embryos and pluripotent stem cells
In this study, we explored x-inactivation in monkey embryos (ICM and TE separately) and pluripotent stem cells (IVF derived ES, SCNT-derived ES and monkey iPS) To elucidate x-inactivation in experimentally reprogrammed pluripotent cells, we derived pluripotent stem cells by both SCNT and iPS approac...
ORGANISM(S): Macaca mulatta 
2012-08-31 | E-GEOD-36252 | biostudies-arrayexpress
ProteomicsSirtuin 7 regulates Xa-hyperactivation to balance the X-chromosome against the genome
Sirtuins are deacetylases implicated in stress responses and longevity in mammals. Although their differential impact on the two sexes has been noted, underlying causes for sex biases in aging and cancer are not known. Here, using Sirtuin 7 (SIRT7) as a model in mice, we probe mechanisms leading to ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD057198 | Pride
Sirt7 Label free Acetylation X-chromosome Phosphorylation Maxquant Ezh2 Sirtuin 7 
ProteomicsHbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
In mammals, chromosome-wide regulatory mechanisms ensure a balance of X-linked gene dosage between males (XY) and females (XX). In female cells, expression of genes from one of the two X-chromosomes is curtailed, with selective accumulation of Xist-RNA, Xist-associated proteins, specific histone mod...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD054014 | Pride
Proteomics Mitotic Mouse Chromosomes 
TranscriptomicsDNA methylation profiles of human active and inactive X chromosomes
X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell. In order to characterize epigenetic changes that accompany this process, we measured DNA methylation levels in both 45,X Turner syndrome patients, who carry...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-22551 | biostudies-arrayexpress
TranscriptomicsXist Repeats A and B account for two distinct phases of X-inactivation establishment
X-chromosome inactivation (XCI) is a global silencing mechanism by which XX and XY mammals equalize X-linked gene dosages. XCI begins with an establishment phase during which Xist RNA spreads and induces de novo heterochromatinization across a female X chromosome, and is followed by a maintenance ph...
ORGANISM(S): Mus musculus 
2020-06-15 | GSE135389 | GEO
GenomicsSirtuin 7 regulates dosage compensation and safeguards the female X-chromosome [ChIP_SIRT7_TTF]
Sirtuins are deacetylases implicated in stress responses and longevity in mammals. Although their differential impact on the two sexes has been noted, underlying causes for sex biases in aging and cancer are not known. Here, using Sirtuin 7 (SIRT7) as a model in mice, we probe mechanisms leading to ...
ORGANISM(S): Mus musculus 
2026-04-07 | GSE256283 | GEO
GenomicsSirtuin 7 regulates dosage compensation and safeguards the female X-chromosome [H3K36Ac_TTF]
Sirtuins are deacetylases implicated in stress responses and longevity in mammals. Although their differential impact on the two sexes has been noted, underlying causes for sex biases in aging and cancer are not known. Here, using Sirtuin 7 (SIRT7) as a model in mice, we probe mechanisms leading to ...
ORGANISM(S): Mus musculus 
2026-04-07 | GSE256282 | GEO
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