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ProteomicsHuh-7 exosomes and HBV
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080794 | MassIVE
ProteomicsPorphyromonas gingivalis infection and atherosclerosis
To explore the effect of Porphyromonas gingivalis on lipid-laden macrophages, the project was conduct. Overall design: 8 samples, 4 replicates in 2 groups, with ox-LDL-treated RAW264.7 macrophages stimulated with or without Porphyromonas gingivalis.
ORGANISM(S): Mus Musculus 
2024-01-09 | PXD048371 |
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
UnknownYY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation.
Not available
S-EPMC7732823 | biostudies-literature
UnknownGlobal and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach.
Not available
S-EPMC10863980 | biostudies-literature
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
Proteomicsβ-thalassemia plasma EVs proteomics
Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the ...
ORGANISM(S): Homo Sapiens 
2022-06-15 | PXD034548 |
ProteomicsThe targets study of HDCA in ameliorating NAFLD induced by high-calories diet by multi-omics technology
HDCA supplementation ameliorated diet-induced NAFLD in C57 wild type mice. In attempt to comprehensively understand the molecular mechanism occurring during the protective effect of HDCA, transcriptomic and proteomic profiles of mouse liver were first analyzed utilizing RNA-Sequencing and Tandem Mas...
ORGANISM(S): Mus Musculus 
2023-08-18 | PXD044613 |
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
UnknownGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535838 | biostudies-literature
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