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UnknownA Prospective Multicenter Study of the Chinese Scoring System for Hepatitis B Liver Failure.
Not available
S-EPMC8592973 | biostudies-literature
MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
ProteomicsCDH11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit
The molecular etiology of numerous risk genes for autism spectrum disorder (ASD), including CDH11, remains elusive. We investigated the role of CDH11 in the development of ASD-related behaviors using gene-deficient mice. CDH11 is enriched at synapses in glutamatergic neurons of the anterior cingulat...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD056411 | Pride
Synaptic adhesion Asd Neuronal activity Proteomics Brain circuit Self-grooming Cdh11 Acc 
ProteomicsProbe mechanism of improved acetic aicd toleranca induced by flocculation in Saccharomyces cerevisiae through phosphoproteome
We constructed non-flocculating strain PLY01 from industrial flocculating strain SPSC01. In the presence of 5.0 g/L acetic aicd stress, SPSC01 showed better growth and fermentation performance compared to PLY01. For probing mechanism of improved acetic acid tolerance induced by flocculation, we perf...
ORGANISM(S): Saccharomyces Cerevisiae 
2021-09-06 | PXD028217 |
UnknownLiquid-liquid phase separation of LARP7 restrains HIV-1 replication.
Not available
S-SCDT-10_1038-S44319-025-00421-9 | biostudies-other
TranscriptomicsRNA-seq of retinal organoids derived from RPGR patient-, control- and mutation-corrected-iPSC at different developmental stages
Retinitis pigmentosa (RP) is an irreversible and inherited retinopathy. RPGR mutations are the most common causes of this disease. It remains challenging to decipher the mechanism of RPGR mutation because of the lack of appropriate study models. The substitution of patient-specific diseased retina w...
ORGANISM(S): Homo sapiens 
2020-02-01 | E-MTAB-6490 | biostudies-arrayexpress
MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
ProteomicsA chaperone-like function of FUS ensures TAZ condensates dynamics and transcriptional activation
The Hippo pathway plays important roles in organ development, tissue homeostasis, and tumor growth, and its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the formation of biomolecular condensates. However, the mechanisms that regulate the biop...
ORGANISM(S): Homo Sapiens 
2023-02-17 | PXD040257 |
ProteomicsSARS-CoV-2 nucleocapsid proetin interactome and SUMOylation
Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected to host-mediated post-translational modifications. Here, we demonstrate that the SARS-CoV-2 nucleocapsid protein (SARS2-NP) ...
ORGANISM(S): Homo Sapiens 
2023-10-24 | PXD046366 |
TranscriptomicsGene Expression Atlas for Human Embryogenesis
Gene expression profiling has provided critical insights into the molecular pathways underlying development of model organisms, however little information is available on regulated gene expression during human embryogenesis. We have now filled this important gap of knowledge by performing genome-wid...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-GEOD-15744 | biostudies-arrayexpress
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