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TranscriptomicsDecidual NK cells Xiong et al 2013
Receptors of the KIR family on maternal Natural Killer cells in the decidua are believed to bind to Ligands such as HLA-C on trophoblast cells invading into the decidua from the placenta during early pregnancy. The resulting responses regulate the extent of trophoblast invasion. Genetic studies have...
ORGANISM(S): Homo sapiens 
2014-04-04 | E-MTAB-1784 | biostudies-arrayexpress
UnknownTransplantation of a beating heart: A first in man.
Not available
S-EPMC9019404 | biostudies-literature
TranscriptomicsLarge-scale multi-species survey of metabolome and lipidome
This dataset was generated with the goal of comparative study of gene expression in three brain regions and two non-neural tissues of humans, chimpanzees, macaque monkeys and mice. Using this dataset, we performed studies of gene expression and gene splicing evolution across species and search of ti...
ORGANISM(S): Macaca mulatta 
2014-05-30 | E-GEOD-49379 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regula...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
TranscriptomicsExpression data from MTDH knockdown in the Hec50co endometrial cancer cell line
Understanding the molecular underpinnings of chemoresistance is vital to design therapies to restore chemosensitivity. In particular, metadherin (MTDH) has been demonstrated to have a critical role in chemoresistance. Over-expression of MTDH has recently been implicated in poor clinical outcome in b...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-26134 | biostudies-arrayexpress
TranscriptomicsSalivary gland during development and onset of xerostomia in murine model of SjM-CM-6gren's syndrome-like disease
Differential gene expression in the salivary gland during development and onset of xerostomia in SjM-CM-6grenM-bM-^@M-^Ys syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from t...
ORGANISM(S): Mus musculus 
2009-04-11 | E-GEOD-15640 | biostudies-arrayexpress
Genomics3D regulatory landscape of human naive pluripotency [ChIP-Seq]
The control of cell identity is orchestrated by transcriptional and chromatin regulators in the context of specific chromosome structures. With the recent isolation of human naive embryonic stem cells (ESCs) representative of the ground state of pluripotency, it is possible to deduce this regulatory...
ORGANISM(S): Homo sapiens 
2015-11-22 | E-GEOD-69646 | biostudies-arrayexpress
UnknownA novel mutation of WFS1 gene leading to increase ER stress and cell apoptosis is associated an autosomal dominant form of Wolfram syndrome type 1.
Not available
S-EPMC8059287 | biostudies-literature
TranscriptomicsDevelopment of gene expression signatures for senecionine exposure
Senecionine is among the most well-studied pyrrolizidine alkaloids, which have caused intense and lasting attention for their significant hepatotoxicity. To develop gene expression approach to senecionine exposure, we have employed whole genome microarray expression profiling as a discovery platform...
ORGANISM(S): Rattus norvegicus 
2013-02-08 | E-GEOD-44144 | biostudies-arrayexpress
UnknownA homozygous PIWIL2 frameshift variant affects the formation and maintenance of human-induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell-only syndrome.
Not available
S-EPMC9509617 | biostudies-literature
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