Sort   by:  
 Page size 
ProteomicsProtein Deacetylase CobB Interplays with c-di-GMP
As a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes like bacterial motility and transcription regulation. We found that c-di-GMP had impact on lysine acetylation level. To further investigate the regulation role, we performed a quantitative analysis of E. ...
ORGANISM(S): Escherichia coli 
2019-06-17 | PXD010558 | Pride
C-di-gmp Ydeh Acetylation 
TranscriptomicsTri-KIX +/- c-Myb MEFs
Transcription profiling by array of wild type and p300 KIX/KIX; CBP +/KIX primary mouse embryonic fibroblasts (MEFs) transduced with either MSCV-c-Myb_IRES-GFP or MSCV-IRES-GFP retrovirus to determine the effect of mutating the KIX domain of CBP and p300 on c-Myb regulated gene expression. CBP KIX ...
ORGANISM(S): Mus musculus 
2014-02-10 | E-MTAB-1973 | biostudies-arrayexpress
ProteomicsSILAC labeling efficiency for c-di-GMP and CobB
Description To determine whether c-di-GMP could affect CobB-dependent deacetylation in a global setting, we applied Stable Isotope Labeling with Amino acids in Cell culture (SILAC) coupled with MS to quantitatively compare the levels of protein acetylation in WT, ΔcobB and ΔdgcZ cells. Before that, ...
ORGANISM(S): Escherichia coli 
2019-06-24 | PXD014344 | Pride
Silac c-di-gmp 
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsTranscription profiling of human HEK293 cells transfected with either wild type or delta exon 4 mutants of surfacant protein C
Mutations in the gene encoding surfactant protein C (SFTPC) have been linked to interstitial lung disease in children and adults. Expression of the index mutation, SP-Cdeltaexon4, in transiently transfected cells and type II cells of transgenic mice resulted in misfolding of the proprotein, activat...
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-2980 | biostudies-arrayexpress
Proteomicsc-di-GMP affect the protein acetylation through CobB dependent deacetylation
To determine whether c-di-GMP could affect CobB-dependent deacetylation in a global setting, we applied Stable Isotope Labeling with Amino acids in Cell culture (SILAC) coupled with MS to quantitatively compare the levels of protein acetylation in WT, ΔcobB and ΔdgcZ cells.
ORGANISM(S): Escherichia coli 
2019-06-17 | PXD013292 | Pride
C-di-gmp cobb 
ProteomicsExpression of a surfactant protein C mutation impairs postnatal expansion of alveolar type 2 epithelial cells leading to permanent cell loss and decreased repair capacity in adult lungs
Mutations in the gene encoding surfactant protein C (SFTPC) are associated with interstitial lung disease in children and adults. To assess the natural history of disease, we knocked-in a familial, disease-associated SFTPC mutation, L188Q (L184Q in mice), into the mouse Sftpc locus. Expression of th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-08-19 | MSV000085976 | MassIVE
ProteomicsDual-Resolving of Positional and Geometric Isomerism of C=Cs via Bifunctional Visible-light-activated Photocycloaddition-Photoisomerization Reaction System
The biological functions of lipids largely depend on their chemicalspatial structures. The position and configuration of C=C bonds are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Her...
ORGANISM(S): Homo Sapiens Arabidopsis Thaliana 
2022-02-19 | PXD031819 |
TranscriptomicsGene array for identifying molecules involved in IL-10 regulation during Th17 polarization
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 pr...
ORGANISM(S): Mus musculus 
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress
ProteomicsLysargiNase and Chemical Derivatization Based Strategy for 2 Facilitating In-Depth Profiling of C‑Terminome
we developed a new method for C-terminomics, in which LysargiNase and chemical derivatization were integrated to increase the identification confidence.
ORGANISM(S): Homo Sapiens 
2019-12-16 | PXD016756 |
Sort   by:  
 Page size