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ProteomicsNeurodegenerative disease mouse model SDS-insoluble proteins
The deposition of pathologic misfolded proteins in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia and amyotrophic lateral sclerosis is hypothesized to burden protein homeostatic (proteostatic) machinery, potentially leading to insufficient capac...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD010828 | Pride
Protein misfolding Transgenic mice Proteomics Lc-ms/ms 
ProteomicsProtein interaction networks for Matrin 3 encoding mutations
To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis (ALS) and distal myopathy, we used transcriptome and interactome analysis. We found over-expression of wild-type (WT) or F115C mutant MATR3 had little impact on gene expression in neuroglia cells. We identified ~123 ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD008896 | Pride
Matrin 3 Interaction 
ProteomicsIdentification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines
Heat-shock is an acute insult to the mammalian proteome. The sudden elevation in temperature has far-reaching effects on protein metabolism, leads to a rapid inhibition of most protein synthesis, and the induction of protein chaperones. Using heat-shock in cells of neuronal (SH-SY5Y) and glial (CCF-...
ORGANISM(S): Homo sapiens (Human) 
2016-04-11 | PXD003914 | Pride
Detergent insoluble Sh-sy5y Heatshock Ccf-sttg1 Cultured cell 
ProteomicsCompare the SDS-insoluble proteins among 7 Amyloidosis mouse models
A hallmark pathology of Alzheimer’s disease (AD) is the formation of amyloid ß (Aß) deposits that exhibit diverse localization and morphologies, ranging from diffuse to cored-neuritic deposits in brain parenchyma, with cerebral vascular deposition in leptomeningeal and parenchymal compartments. Most...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-15 | PXD017916 | Pride
Protein homoestasis Transgenic mice Detergent-insoluble proteins Amyloid Alzheimer's disease 
ProteomicsIdentification of Proteins Sensitive to Thermal Stress in Human HEK293 cells
Heat-shock is an acute insult to the mammalian proteome. The sudden elevation in temperature has far-reaching effects on protein metabolism, leads to a rapid inhibition of most protein synthesis, and the induction of protein chaperones. Using heat-shock in human HEK293 cells, in conjunction with det...
ORGANISM(S): Homo sapiens (Human) 
2016-04-11 | PXD003888 | Pride
Detergent insoluble Hek293 Heat shock Sh-sy5y Ccf-sttg1 Lc-ms/ms 
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