In this study, we evaluated the antimicrobial properties of XN and C. butyricum culture supernatant (CBs) against C. difficile, focusing on their ability to reduce C. difficile adhesion, inhibit growth, and restrict toxin production. Using a dextran sulfate sodium (DSS)-induced Caco-2 intestinal epi...
Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's
narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host
genetic factors have been ...
Cholesterol of the host macrophage membrane is vital for mycobacterial infection, replication, and persistence. During chronic infection within host lung tissues, cholesterol facilitates the phagocytosis of mycobacteria into macrophages. Cholesterol degradation leads to increased flux of acetyl-coenz...
we developed a new method for C-terminomics, in which LysargiNase and chemical derivatization were integrated to increase the identification confidence.
The present study had a total of 125 primary prostate cancer samples collected with paired non-tumor adjacent lung tissues from the treatment-naïve Chinese patients and proteogenomic analysis was performed.
This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...
We used EZH2i-targeted hematological malignancies as an examples and focused on molecular characterization of EZH2 Y641 mutant hematological cell lines. We used the proteomic strategies and compared the protein expression level and lysine methylation level (including mono-, di-, and trimethylaiton) ...
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
