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TranscriptomicsExpression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
Statins and bisphosponates (BPs) are two distinct classes of isoprenoid pathway inhibitors targeting HMG-CoA reductase (upstream enzyme) and Farnesyl-pyrophospate synthase (downstream enzyme) respectively. Here we conducted a comparative study of two representatives of these classes, fluvastatin (Fl...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33552 | biostudies-arrayexpress
TranscriptomicsPhysiological and molecular characterization of genetic competence in Streptococcus sanguinis
Streptococcus sanguinis is a major component of the oral flora and an important cause of infective endocarditis. The genome sequence of S. sanguinis strain SK36 was recently determined. A number of foreign genes acquired by natural transformation were detected, as well as orthologs of competence gen...
ORGANISM(S): Streptococcus sanguinis 
2011-01-21 | E-GEOD-21619 | biostudies-arrayexpress
TranscriptomicsGenome-wide mapping of Rad21 binding sites and gene expression profiling in wild type mouse small intestinal epithelial crypts and Apc Min adenomas
To investigate the role of RAD21 in the transcriptional regulation of global gene expression at early stage of colorectal cancer developments, we peformed the genome-wide analysis to map genomic regions bound by Rad21 in normal small testinal crypts and tumors (adenomas) harvested from Apc Min/+ mic...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-59283 | biostudies-arrayexpress
ProteomicsAffinity purification of biotinylated AtACINUS and Mass Spectrometric analysis to identify PTMs on AtACINUS
AtACINUS protein is involved in regulation of alternative transcription and splicing (AS). Previously we have identified O-GlcNAcylation and phosphorylation sites on AtACINUS using LWAC and IMAC enrichment (Xu et al., 2017). To identify more modification sites, we have created AtACINUS-YFP-TurboID/a...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-12-02 | PXD020749 | Pride
Seedling Acinus Plant Co-immunoprecipitation Arabidopsis thaliana atacinus O-glcnacylation Ip-ms Phosphorylation O-fucosylation Lc-ms/ms 
ProteomicsProteomics study on caffeine for 10 min
Proteomics study on the HepG2 cells which were treated with 6 doses of caffeine for 10 min
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD030943 |
TranscriptomicsExpression data of Actinobacillus pleuropneumoniae 4074 and the M-NM-^TluxS mutant of Actinobacillus pleuropneumoniae 4074
LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofi...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2011-11-09 | E-GEOD-19056 | biostudies-arrayexpress
ModelsXu2003 - Phosphoinositide turnover
Xu2003 - Phosphoinositide turnover The model reproduces the percentage change of PIP_PM, PIP2_PM and IP3_Cyt as depicted in Figure 1 of the paper. The model also contains the equations for the analysis of PH-GFP experiments, however the initial value of PH_GFP has been set to zer...
2024-09-02 | BIOMD0000000075 | BioModels
TranscriptomicsStructural basis of YTH domain as m6A reader
The N6-methyladenosine (m6A) is the most abundant internal modification in almost all eukaryotic messenger RNAs, and is dynamically regulated. Therefore, identification of m6A readers is especially important in determining the cellular function of m6A. YTHDF2 has recently been characterized as the f...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-58352 | biostudies-arrayexpress
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
UnknownApc(MIN) modulation of vitamin D secosteroid growth control.
Not available
S-EPMC2915628 | biostudies-literature
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