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ProteomicsSerum proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The serum samples from wild type mice fed high-fat diet for 12 weeks (WT_Serum) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (KI_Serum) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectrometry-based proteomics tec...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034069 | Pride
Serum Proteomics Mice Wild type Mdm2 
ProteomicsThe eWAT proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034074 | Pride
Proteomics Ewat Mice Mdm2 High-fat diet 
UnknownInhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity.
Not available
S-EPMC9548188 | biostudies-literature
ProteomicsHDAC1 K412 lactylation acts as an intrinsic metabolic barrier against p53-dependent osteoblast apoptosis in glucocorticoid-induced osteoporosis
4D Label-free Lactylomics: Primary osteoblasts derived from Dex- or Dex/NaLa-treated mice were lysed in lysis buffer containing 8 M urea and protease/phosphatase inhibitors. After reduction and alkylation, proteins were digested with trypsin overnight. Peptides were incubated with pan-anti-lactyllys...
ORGANISM(S): Mus Musculus 
PXD084853 |
TranscriptomicsTranscriptome profile of liver at different physiological stages in laying hens
In this study, RNA-Seq technology was adopted to investigate the differences in expression profiles of the hepatic lipid metabolism-related genes and the associated pathways between juvenile and laying hens. RNA-Seq analysis was carried out to estimate total RNA harvested from the liver of juvenile ...
ORGANISM(S): Gallus gallus 
2016-01-08 | E-GEOD-70010 | biostudies-arrayexpress
TranscriptomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (RNA-seq)
Aberrant DNA hypermethylation of CpG island (CGI) promoters are associated with transcriptional repression of many tumor suppressor genes and lead to tumor progression in many cancers. Most recently, one research group observed that aberrantly hypermethylated genes in multiple cancers are already re...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43093 | biostudies-arrayexpress
ProteomicsThe eWAT ubiquitinome of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to ubiquitinome study by Label-free quantification and ubiquitination modifi...
ORGANISM(S): Mus Musculus 
PXD034127 |
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (ChIP-BS)
The model describing that aberrant CpG island (CGI) methylation leads to transcription repression of tumor suppressor genes and thereby is implicated in tumor progression has been established in many cancers. However, recent studies indicated aberrantly hypermethylated genes in multiple cancers are ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43094 | biostudies-arrayexpress
ProteomicsA Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening
In this study, applying a novel knowledge-based, multi-stage discovery and validation strategy we scaled down from 108 diabetes–associated metabolites to a diagnostic metabolite triplet (Met-T) and it could improve the diagnostic accuracy of prediabetes and diabetes screening.
ORGANISM(S): Homo Sapiens 
2020-11-30 | PXD022801 |
ProteomicsMulti-omics profiling reveals the adaptability response of high-temperature of largemouth bass (Micropterus salmoides)
4D-DIA proteome analysis of different tissues of largemouth bass at different time under high temperature stress provide a unique perspective for the analysis of high temperature adaptation mechanism of fish.
ORGANISM(S): Danio Rerio 
PXD055322 |
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