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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
ProteomicsQuantitative proteomic and phosphoproteomic profiling of Sh3rf3-deficient ASD mouse model via 6Plex-TMT and phosphoproteomic
This study aims to systematically investigate the molecular mechanisms underlying autism spectrum disorder (ASD) by analyzing the proteome and phosphoproteome of a Sh3rf3-deficient mouse model. SH3RF3 (SH3 domain-containing RING finger protein 3) is implicated in synaptic regulation pathways, yet it...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD061722 | Pride
Prefrontal cortex Mouse Ms Sh3rf3 
ProteomicsIdentification of Sh3rf3-interacting proteins in mouse prefrontal cortex by immunoprecipitation mass spectrometry
Sh3rf3 is an ASD-associated gene,Sh3rf3 deficiency reduces excitatory synaptic strength in prefrontal cortex and decreases the readily releasable vesicle pool and attenuated vesicle replenishment.To delve into the underlying mechanisms for impaired excitatory transmission, we performed immunoprecipi...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD061685 | Pride
Prefrontal cortex Mouse Ip-ms Sh3rf3 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087949 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087954 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 6
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087955 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 3
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087953 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 4
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087952 | MassIVE
ProteomicsChicken ovary rapid DIA proteome data
Ovarian tissue samples were collected from six Taihe Black-boned fowls during the peak and decline periods of egg production.
ORGANISM(S): Gallus Gallus 
2024-12-20 | PXD059077 |
ProteomicsProteomic analysis of GM-CSF and M-CSF polarized bone marrow derived macrophages
Bone marrow cells were isolated, primed with M-CSF (M-BMDM) or GM-CSF (GM-BMDM) and cultured for 7 days. The proteomic difference between GM-BMDM and M-BMDM were analyzed to describe the phenotye and function of two types of macrophages.
ORGANISM(S): Mus Musculus 
PXD041180 |
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